Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Long-term Potentiation01:35

Long-term Potentiation

56.9K
Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre- and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
56.9K
Long-term Potentiation01:25

Long-term Potentiation

3.0K
Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
Hebbian LTP
LTP can occur when...
3.0K
Mnemonic Devices01:23

Mnemonic Devices

236
Mnemonic devices are cognitive tools that facilitate memory retention by linking new information to familiar patterns or organizational strategies. These techniques are beneficial for remembering complex or lengthy sets of information by simplifying and structuring them in easily retrievable ways.
Acronyms
Acronyms are created by using the initial letters of a series of words to form a new word or phrase. This approach condenses complex information into a single, memorable entity. For example,...
236

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Impact of Sociodemographic Disparities on Health-Related Quality of Life for Adults with Gliomas.

Cancers·2026
Same author

Clinical Reasoning: An 83-Year-Old Female Patient With a Pupil-Involving Oculomotor Nerve Palsy.

Neurology·2025
Same author

Long-term survival, patterns of progression, and patterns of use for patients with newly diagnosed glioblastoma treated with or without Tumor Treating Fields (TTFields) in a real-world setting.

Journal of neuro-oncology·2025
Same author

Implementation and Efficacy of Total Wellness: A Community-Based Cancer Prevention and Lifestyle Intervention Program.

Journal of cancer education : the official journal of the American Association for Cancer Education·2025
Same author

Treatment of Extraneural Metastases of Myxopapillary Ependymomas With Dose-Dense Temozolomide and Lapatinib.

Cureus·2024

Related Experiment Video

Updated: Nov 8, 2025

Shuttle Box Assay as an Associative Learning Tool for Cognitive Assessment in Learning and Memory Studies using Adult Zebrafish
08:35

Shuttle Box Assay as an Associative Learning Tool for Cognitive Assessment in Learning and Memory Studies using Adult Zebrafish

Published on: July 12, 2021

4.7K

Discovering Memory: Using Sea Slugs to Teach Learning and Memory.

Devon C Riegel1

  • 1School of Psychology and Neuroscience, University of St. Andrews, St. Andrews, UK KY16 9JP.

Journal of Undergraduate Neuroscience Education : JUNE : a Publication of FUN, Faculty for Undergraduate Neuroscience
|April 21, 2021
PubMed
Summary
This summary is machine-generated.

Synapse-specific long-term potentiation in Aplysia californica relies on local protein synthesis. However, synaptic capture, where one synapse recruits proteins from another, does not require local protein synthesis, revealing new insights into memory mechanisms.

Keywords:
Aplysia californicacontroversylearning and memorylong term potentiation (LTP)synaptic capture

More Related Videos

Assessing Spatial Learning and Memory in Small Squamate Reptiles
08:44

Assessing Spatial Learning and Memory in Small Squamate Reptiles

Published on: January 3, 2017

7.7K
Aversive Associative Learning and Memory Formation by Pairing Two Chemicals in Caenorhabditis elegans
07:17

Aversive Associative Learning and Memory Formation by Pairing Two Chemicals in Caenorhabditis elegans

Published on: June 23, 2022

2.7K

Related Experiment Videos

Last Updated: Nov 8, 2025

Shuttle Box Assay as an Associative Learning Tool for Cognitive Assessment in Learning and Memory Studies using Adult Zebrafish
08:35

Shuttle Box Assay as an Associative Learning Tool for Cognitive Assessment in Learning and Memory Studies using Adult Zebrafish

Published on: July 12, 2021

4.7K
Assessing Spatial Learning and Memory in Small Squamate Reptiles
08:44

Assessing Spatial Learning and Memory in Small Squamate Reptiles

Published on: January 3, 2017

7.7K
Aversive Associative Learning and Memory Formation by Pairing Two Chemicals in Caenorhabditis elegans
07:17

Aversive Associative Learning and Memory Formation by Pairing Two Chemicals in Caenorhabditis elegans

Published on: June 23, 2022

2.7K

Area of Science:

  • Neuroscience
  • Molecular Biology
  • Cell Biology

Background:

  • The sea slug Aplysia californica is a model organism for studying learning and memory.
  • Synapses exhibiting long-term potentiation are crucial for memory formation.
  • Understanding conserved principles of synaptic plasticity is essential for neuroscience research.

Purpose of the Study:

  • To investigate the molecular mechanisms of synapse-specific long-term potentiation.
  • To explore the role of local protein synthesis in long-term potentiation.
  • To examine the phenomenon of synaptic capture and its requirements.

Main Methods:

  • Electrophysiological recordings from Aplysia neurons.
  • Biochemical assays to detect protein synthesis.
  • Confocal microscopy to visualize protein localization.

Main Results:

  • Synapse-specific long-term potentiation requires local protein synthesis.
  • Synaptic capture, a mechanism where one synapse recruits proteins from another, does not require local protein synthesis.
  • This finding opened new avenues for research into memory consolidation.

Conclusions:

  • Local protein synthesis is critical for establishing synapse-specific long-term potentiation.
  • Synaptic capture represents a distinct mechanism for synaptic plasticity, independent of local protein synthesis.
  • This research provides a foundation for understanding the molecular basis of long-term memory and offers educational value for students.