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Published on: May 23, 2021
Emerging evidence for a mechanistic link between low-frequency oscillation of ventricular repolarization measured
Peter Taggart1, Esther Pueyo2,3, Stefan van Duijvenboden1
1Department of Cardiovascular Sciences, University College London, London, UK.
Abstract:
Strong recent clinical evidence links the presence of prominent oscillations of ventricular repolarization in the low-frequency range (0.04-0.15 Hz) to the incidence of ventricular arrhythmia and sudden death in post-MI patients and patients with ischaemic and non-ischaemic cardiomyopathy. It has been proposed that these oscillations reflect oscillations of ventricular action potential duration at the sympathetic nerve frequency. Here we review emerging evidence to support that contention and provide insight into possible underlying mechanisms for this association.
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