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Updated: Nov 8, 2025

Assessment of Morphine-induced Hyperalgesia and Analgesic Tolerance in Mice Using Thermal and Mechanical Nociceptive Modalities
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First-line methadone for cancer pain: titration time analysis

Guillermo Mammana1, Mariela Bertolino1, Eduardo Bruera2

  • 1Unidad de Cuidados Paliativos - Fundación FEMEBA, Hospital de Agudos Dr. E. Tornú, Buenos Aires, Argentina.

Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer
|April 21, 2021
PubMed
Summary

Low-dose methadone effectively manages cancer pain in palliative care. This study shows rapid pain reduction with minimal rescue doses and no significant side effects, making it a viable first-line treatment.

Keywords:
Advanced cancerCancer painFirst-line methadoneTitration

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