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The role of probiotics and postbiotics in modulating the gut microbiome-immune system axis in the pediatric age

Laura Carucci1,2, Serena Coppola1,2, Anna Luzzetti1,2

  • 1Department of Translational Medical Science, Federico II University, Naples, Italy.

Minerva Pediatrics
|April 21, 2021
PubMed

Insights

The gut microbiome-immune system axis is crucial for immunity. Interventions like probiotics and postbiotics can positively modulate this axis, offering new strategies for pediatric health conditions.

Area of Science:

  • Microbiology
  • Immunology
  • Pediatrics

Background:

  • The gut microbiome significantly influences the human immune system via the gut microbiome-immune system axis.
  • Optimal function of this axis maintains host-microorganism symbiosis and beneficial immune responses.
  • Dysfunction of this axis is linked to pediatric conditions like allergies and autoimmune disorders.

Purpose of the Study:

  • To explore the role of the gut microbiome-immune system axis in health and disease.
  • To investigate environmental factors affecting this axis.
  • To highlight the potential of interventional strategies for pediatric conditions.

Main Methods:

  • Review of current scientific literature on the gut microbiome and immune system interactions.
  • Analysis of evidence on environmental modulators of the gut microbiome-immune system axis.
  • Evaluation of interventional strategies, including diet, probiotics, and postbiotics.

Main Results:

  • The gut microbiome-immune system axis is vital for immune development and function.
  • Environmental factors can positively or negatively impact this axis, affecting health.
  • Probiotics and postbiotics show promise in modulating this axis for pediatric conditions.

Conclusions:

  • The gut microbiome-immune system axis is a key factor in maintaining health.
  • Prenatal and postnatal interventions targeting this axis can improve immune function.
  • Probiotics and postbiotics offer innovative therapeutic and preventive approaches for pediatric diseases.

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