Targeting macrophages using nanoparticles: a potential therapeutic strategy for atherosclerosis
Xinlong Zang1, Mingyang Cheng, Xiaoxu Zhang
1School of Basic Medicine, Qingdao University, Ningxia Road 308, Qingdao, P. R. China. zangxinlong@126.com.
Journal of Materials Chemistry. B
|April 21, 2021
Summary
Macrophages are key in atherosclerosis development and plaque instability. Targeting these cells with nanoparticle drug delivery offers a promising therapeutic strategy to combat this widespread vascular disease.
Area of Science:
- Cardiovascular Research
- Nanomedicine
- Immunology
Background:
- Atherosclerosis is a major global cause of vascular disease, characterized by inflammation and plaque buildup.
- Macrophages are central players in atherosclerosis, driving inflammation and plaque rupture, making them a key therapeutic target.
Purpose of the Study:
- To review strategies for modulating macrophage activity in atherosclerosis.
- To discuss the development and evaluation of nanomedicines designed to target intraplaque macrophages for anti-atherosclerosis therapy.
Main Methods:
- Literature review of macrophage-targeting strategies in atherosclerosis.
- Analysis of nanoparticle-based delivery systems for therapeutic agents into macrophages.
- Evaluation of current challenges and future prospects for clinical application.
Main Results:
- Macrophages critically influence atherosclerosis progression and plaque stability.
- Nanoparticle systems offer targeted delivery of therapeutics to intraplaque macrophages.
- Development of macrophage-targeting nanomedicines holds potential for improved treatment outcomes.
Conclusions:
- Targeting macrophages is a viable strategy for treating atherosclerosis.
- Nanoparticle-based drug delivery systems show promise for selective macrophage targeting.
- Further research and development are needed to overcome challenges for clinical translation.
