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Updated: Nov 8, 2025

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems
Published on: June 13, 2025
[Cornerstones of evidence-based health information]
1Ressort Gesundheitsinformation, Institut für Qualität und Wirtschaftlichkeit im Gesundheitswesen (IQWiG), Im Media Park 8, 50670, Köln, Deutschland. klaus.koch@iqwig.de.
Abstract:
Evidence-based health information is intended to empower people to make informed health decisions and include their personal goals and expectations by providing them with neutral and understandable content. To achieve this, a number of requirements must be followed in the production of health information, which are described in this article. These include, among other things, systematic research, a reasoned selection of appropriate evidence, and consideration of current evidence to communicate numbers, risks, and probabilities. Implementation must also take into account the issues, competencies and usage patterns of the groups for which the information is intended. A number of German-language information services demonstrate that implementation of these requirements is feasible for the general public.
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