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Small bowel T-cell lymphoma: a MEITL-ing diagnosis
Sheena Mago1, Marianna Mavilia2, Faripour Forouhar3
1Department of Medicine, University of Connecticut Health Center, Farmington, CT, USA.
Clinical Journal of Gastroenterology
|April 21, 2021
Summary
Monomorphic epitheliotropic intestinal T-cell lymphoma (MEITL) is a rare, aggressive cancer. Early diagnosis through endoscopic and histological evaluation is crucial for prompt treatment and improved outcomes in patients with this challenging gastrointestinal lymphoma.
Area of Science:
- Gastroenterology and Oncology
- Hematology
- Pathology
Background:
- Monomorphic epitheliotropic intestinal T-cell lymphoma (MEITL), formerly Type-II enteropathy-associated T-cell lymphoma (EATL), is a rare and aggressive non-Hodgkin lymphoma.
- MEITL is characterized by a poor prognosis and often presents with nonspecific gastrointestinal symptoms, complicating early diagnosis.
Observation:
- A case of a 59-year-old male with a 2-week history of abdominal distention is presented.
- Endoscopic examination revealed a non-bleeding, ulcerated segment in the proximal jejunum.
- Histological analysis confirmed the presence of MEITL.
Findings:
- The patient's symptoms and endoscopic findings were consistent with MEITL.
- The rarity and nonspecific presentation of MEITL highlight diagnostic challenges.
Implications:
- This case underscores the importance of recognizing the endoscopic and histological features of MEITL.
- Prompt diagnosis and treatment are essential for managing this aggressive gastrointestinal lymphoma.
- Further research into the early detection and management of MEITL is warranted.
Keywords:
EATLMEITLMonomorphic epitheliotropic intestinal T-cell lymphomaType-II enteropathy-associated T-cell lymphoma
