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Updated: Nov 8, 2025

Robot-assisted Total Mesorectal Excision and Lateral Pelvic Lymph Node Dissection for Locally Advanced Middle-low Rectal Cancer
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Evolution and Current Status of the Multidisciplinary Management of Locally Advanced Rectal Cancer
Benjamin W Deschner1, Noam A VanderWalde2, Axel Grothey2
1Division of Surgical Oncology, Department of Surgery, University of Tennessee Health Science Center, Memphis, TN.
Abstract:
The management of locally advanced rectal cancer has grown in both complexity and quality since the first proctectomy. What once was a malignancy with a fairly consistent treatment algorithm for decades, a recent paradigm shift in the care of these patients has led to a more personalized, multidisciplinary approach with variations in timing, sequence, duration, and potential exclusion of multimodality therapies. This review summarizes the most important evidence behind these developing overarching concepts to provide a context for this paradigm shift.
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