Vaccine Breakthrough Infections with SARS-CoV-2 Variants
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View abstract on PubMed
Summary
This summary is machine-generated.Fully vaccinated individuals can still contract SARS-CoV-2 variants. This study found breakthrough infections in two women despite vaccination, highlighting the need for ongoing variant surveillance.
Area Of Science
- Virology
- Immunology
- Epidemiology
Background
- Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants pose a significant public health challenge.
- Vaccination is a primary strategy to prevent coronavirus disease 2019 (COVID-19).
Observation
- Two women in a cohort of 417 individuals experienced vaccine breakthrough infections.
- Both women had received two doses of either BNT162b2 (Pfizer-BioNTech) or mRNA-1273 (Moderna) vaccine at least two weeks prior.
Findings
- Despite vaccine efficacy, both women developed COVID-19 symptoms and tested positive for SARS-CoV-2.
- Viral sequencing identified concerning variants, including E484K in one case and T95I, del142-144, and D614G mutations in both.
Implications
- Vaccinated individuals remain at potential risk of infection with SARS-CoV-2 variants.
- Continued efforts are crucial for infection prevention, diagnosis, and characterization of variants in vaccinated populations.
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