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Engineering hydrogels for personalized disease modeling and regenerative medicine
Ian M Tayler1, Ryan S Stowers2
1Department of Molecular, Cellular, and Developmental Biology, University of California, Santa Barbara, Santa Barbara, CA, United States.
Acta Biomaterialia
|April 21, 2021
Summary
Hydrogels create artificial cellular environments for personalized medicine, enabling engineered tissues and disease models. Advances in hydrogel design and bioprinting are key to realizing personalized medicine
Area of Science:
- Biomaterials Science
- Regenerative Medicine
- Tissue Engineering
Background:
- Personalized medicine relies on patient-specific data and cellular models.
- Hydrogels offer tunable microenvironments for cell manipulation and tissue creation.
Purpose of the Study:
- To review hydrogel applications in personalized medicine.
- To highlight hydrogel strategies for stem cell control and tissue engineering.
- To discuss hydrogels in personalized disease modeling and drug screening.
Main Methods:
- Engineering hydrogels to control stem cell differentiation and reprogramming.
- Combining hydrogels with organoids, advanced imaging, and bioprinting.
- Utilizing hydrogels for in vitro disease modeling and drug screening.
Main Results:
- Hydrogels facilitate the generation of functional engineered tissues.
- Hydrogel systems enable personalized in vitro disease models for fibrosis and cancer.
- Hydrogels support drug screening using patient-derived cells.
Conclusions:
- Engineered hydrogels are crucial for advancing personalized medicine.
- Hydrogel-based strategies are vital for personalized tissue engineering and disease modeling.
- Continued innovation in hydrogels will unlock the potential of personalized medicine.
