Regression analysis of arbitrarily censored survival data under the proportional odds model

Arbitrarily censored data are referred to as the survival data that contain a mixture of exactly observed, left-censored, interval-censored, and right-censored observations. Existing research work on regression analysis on arbitrarily censored data is relatively sparse and mainly focused on the proportional hazards model and the accelerated failure time model. This article studies the proportional odds (PO) model and proposes a novel estimation approach through an expectation-maximization (EM) algorithm for analyzing such data. The proposed EM algorithm has many appealing properties such as being robust to initial values, easy to implement, converging fast, and providing the variance estimate of the regression parameter estimate in closed form. An informal diagnosis plot is developed for checking the PO model assumption. Our method has shown excellent performance in estimating the regression parameters as well as the baseline survival function in a simulation study. A real-life dataset about metastatic colorectal cancer is analyzed for illustration. An R package regPO has been created for practitioners to implement our method.