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Sensory Function and Psychological Factors in Children With Complex Regional Pain Syndrome Type 1

Emma E Truffyn1, Massieh Moayedi2, Stephen C Brown3

  • 1Applied Psychology, 151153Western University, London, Ontario, Canada.

Journal of Child Neurology
|April 22, 2021
PubMed

Insights

Children with Complex Regional Pain Syndrome Type 1 (CRPS-I) may experience altered cold pain sensitivity and increased anxiety. Pain duration and psychosocial factors influence sensory perception in pediatric CRPS-I.

Area of Science:

  • Pediatric Pain Management
  • Neuroscience
  • Psychology

Background:

  • Complex Regional Pain Syndrome Type 1 (CRPS-I) is a debilitating condition in children.
  • Understanding the interplay between sensory processing and psychosocial factors is crucial for effective CRPS-I management.
  • Current research lacks comprehensive data on thermal-sensory perception and psychological correlates in pediatric CRPS-I.

Purpose of the Study:

  • To compare thermal-sensory thresholds between children with CRPS-I and healthy controls.
  • To investigate the association between pain duration, intensity, and psychosocial factors (anxiety, social stress) with sensory perception in pediatric CRPS-I.
  • To explore potential neurophysiological mechanisms underlying sensory alterations in CRPS-I.

Main Methods:

  • Quantitative sensory testing (QST) using warm, cool, heat, and cold stimuli on the forearm.
  • Inclusion of 34 children with CRPS-I and 56 pain-free controls.
  • Administration of the Behavior Assessment System for Children (BASC) to assess psychosocial factors.

Main Results:

  • Longer pain duration (>5.1 months) in CRPS-I patients correlated with reduced cold pain sensitivity at the affected site (P = .04).
  • Higher pain intensity ratings were significantly associated with elevated anxiety scores (P = .03).
  • Anxiety and social stress demonstrated a significant association with warmth sensitivity on the contralateral, non-pain site (P < .05).

Conclusions:

  • Pain duration is a critical factor in the assessment of pediatric CRPS-I.
  • Emergent hyposensitivity in the affected limb may indicate nociceptive nerve degeneration.
  • Anxiety appears to play a significant role in modulating thermal-sensory perception in children with CRPS-I.
Abstract

Keywords:
CRPSQSTadolescentsanxietychildrendepressionpain

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