[The possibility of predicting the development of bronchial asthma]

A total of 235 patients with bronchial asthma and preasthma and their 85 relatives of the 1st degree of kinship were investigated. A detailed clinicofunctional and immunological investigation including a study of histocompatibility antigens, revealed the relationships between bronchial asthma development and antigens A2, B13, B21, B35 carriage. The authors presented a complex of methods (provocative acetylcholine tests, anaprilin test, determination of HLA antigens) permitting the prediction of this disease in patients with an aggravated hereditary and allergological history at the preclinical stage.