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Fluorescence detection methods for microfluidic droplet platforms
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Small-volume detection: platform developments for clinically-relevant applications.

Wei-Hsuan Sung1, Yu-Ting Tsao1, Ching-Ju Shen2

  • 1Chang Gung Memorial Hospital, Linkou Medical Center and Chang Gung Medical College and Chang Gung University, Taoyuan, Taiwan.

Journal of Nanobiotechnology
|April 22, 2021
PubMed
Summary
This summary is machine-generated.

Small-volume diagnostic devices offer rapid, portable, and inexpensive disease detection using minimal body fluid samples. This review highlights recent advances in point-of-care diagnostics for various medical fields.

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Area of Science:

  • Biomedical Engineering
  • Point-of-Care Diagnostics
  • Clinical Chemistry

Background:

  • Biochemical analysis of human body fluids is crucial for disease diagnosis.
  • Point-of-care (POC) diagnostics enable rapid results outside traditional labs.
  • Small-volume detection devices offer portability, low cost, and minimal sample needs, but are under-discussed.

Purpose of the Study:

  • To review recent progress (since 2015) in small-volume detection strategies for clinical samples.
  • To summarize developments in ophthalmology, dermatology, otolaryngology, and cerebrospinal fluid analysis.
  • To discuss applications in other bodily fluids like semen and cervico-vaginal fluids.

Main Methods:

  • Literature review focusing on small-volume detection strategies using clinical samples from the last five years.
  • Analysis of studies detailing diagnostic applications in specific medical fields.
  • Examination of associated collection and detection devices and approaches.

Main Results:

  • Advances in ophthalmology enable analysis of tear/anterior chamber fluid for conditions like diabetic mellitus and dry-eye disease.
  • Small-volume strategies aid wound monitoring, healing assessment, and autoimmune disease diagnosis via blister fluid.
  • Applications in otolaryngology, cerebrospinal fluid analysis, semen, and cervico-vaginal fluids show diagnostic potential.

Conclusions:

  • Small-volume detection devices represent a significant advancement in point-of-care diagnostics.
  • These technologies offer improved early detection and monitoring across diverse medical specialties.
  • Further research and development in this area promise enhanced patient care and outcomes.