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Selective Modulation of a Pan-Essential Protein as a Therapeutic Strategy in Cancer

Clare F Malone1,2,3, Neekesh V Dharia1,2,3,4, Guillaume Kugener2

  • 1Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.

Cancer Discovery
|April 22, 2021
PubMed
Summary

Researchers identified NXT1 as a lethal genetic dependency in neuroblastoma. Exploiting the NXT1-NXT2 paralog relationship offers a strategy to selectively eliminate the essential NXF1 protein in tumor cells, minimizing toxicity.

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