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Assessment of Kidney Function in Mouse Models of Glomerular Disease
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Glomerular Filtration Dysfunction is Associated with Cardiac Adverse Remodeling in Menopausal Diabetic Chinese Women

Xing Song1, Gang Li1, Yuqi Zhu1

  • 1Division of Cardiology, Department of Geriatrics, The First Affiliated Hospital of Chongqing Medical University, Chongqing, People's Republic of China.

Clinical Interventions in Aging
|April 22, 2021
PubMed

Insights

Impaired kidney function in menopausal women with type 2 diabetes is linked to adverse heart changes. This study highlights the connection between reduced glomerular filtration rate and cardiac remodeling in this population.

Area of Science:

  • Cardiology
  • Nephrology
  • Endocrinology

Background:

  • Nephropathy is known to affect cardiac structure and function in diabetic adults.
  • Limited data exists on the link between glomerular filtration dysfunction and cardiac remodeling specifically in menopausal diabetic women.

Purpose of the Study:

  • To investigate the association between impaired glomerular filtration function and cardiac adverse remodeling.
  • Focus on menopausal Chinese women diagnosed with type 2 diabetes mellitus (DM).

Main Methods:

  • Retrospective analysis of 1231 hospitalized menopausal Chinese women with type 2 DM.
  • Cross-sectional echocardiography data compared across estimated glomerular filtration rate (eGFR) categories.

Main Results:

  • Moderate to severe glomerular filtration dysfunction (eGFR <60 mL/min/1.73m²) correlated with adverse cardiac remodeling.
  • Observed associations included enlarged left-side chambers, increased ventricular wall thickness, reduced cardiac function, and right ventricle dilation (P < 0.05).

Conclusions:

  • Glomerular filtration dysfunction is significantly associated with cardiac adverse structural remodeling.
  • Cardiac dysfunction is also linked to impaired kidney function in this specific demographic.
Abstract

Keywords:
agingcardiac remodelingglomerular filtration ratemenopausal womentype 2 diabetes mellitus

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