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Updated: Nov 8, 2025

Taste Exam: A Brief and Validated Test
Published on: August 17, 2018
Comparative taste-masking evaluation of microencapsulated bitter drugs using Smartseal 30D and ReadyMix for
Leona Chidinma Muoka1, Steven A Ross2,3, Md Sadeque Hossain Mithu1,3
1Faculty of Engineering and Science, University of Greenwich, Medway Campus, ME4 4TB, Chatham Maritime, Kent, UK.
Abstract:
The taste of drug substances plays a key role in the development of paediatric formulations with suitable organoleptic properties. The aim of the study was to evaluate the taste masking effectiveness of Smartseal 30D and ReadyMix on a range of bitter drug substances such as diphenhydramine HCl (DPD), ibuprofen lysine (IBU-LS), and phenylephrine HCl (PPH) for the development of paediatric dosage forms. The drugs were microencapsulated in the polymer carriers at 10-20% loadings using spray-drying processing. Spray drying of drug formulations was optimized in terms of percent yield and encapsulation efficiency followed by physicochemical characterization in order to identify the drugs' physical state in the polymer microparticles. The in vivo taste masking efficiency was evaluated using human test panel and showed noticeable reduction of drug's bitterness at all loadings in comparison to the bulk substances.
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