Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Role of Vitamins in Maintaining Bone Health

Role of Vitamins in Maintaining Bone Health

The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...

Essential Minerals for Bone Health

Essential Minerals for Bone Health

The minerals contained in all of the food we consume are essential for our organ systems. However, certain essential minerals, such as calcium, phosphorus, magnesium, manganese, and fluoride, largely affect bone health.
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...

Hormones and Bone Tissue

Hormones and Bone Tissue

The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...

Bone Disorders

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...

Bone Remodeling

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.

The Bone Matrix

The Bone Matrix

Bone contains a relatively small number of cells entrenched in a matrix of collagen fibers that provide an adherent surface for inorganic salt crystals. Both components of the matrix, organic and inorganic, contribute to the unusual properties of bone. Without collagen, bones would be brittle and shatter easily. Without mineral crystals, bones would flex and provide little support. This can be observed by an experiment: when the minerals of a bone are dissolved by soaking the bone in...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

On-Chip Generation of Copolarized and Spectrally Separable Photon Pairs.

Physical review letters·2026

Same author

Remodeling of the immune-metabolic landscape triggered by long-term high-altitude exposure.

Cell reports·2026

Same author

<i>NDUFS6</i> promotes neuroblastoma progression and represents a potential therapeutic target.

Translational pediatrics·2026

Same author

New dibenzofurans from Phellinus ribis and their anti-inflammatory activity.

Fitoterapia·2026

Same author

WTAP-mediated m<sup>6</sup>A methylation of CEP55 promotes immune evasion in lung adenocarcinoma by activating the PI3K/AKT/mTOR pathway.

Molecular genetics and genomics : MGG·2026

Same author

Phase measurement and compensation method for a waveguide beam based on an on-chip 90° optical hybrid mixer.

Optics express·2026

Search research articles

Related Experiment Video

Updated: Nov 8, 2025

Author Spotlight: Comparing Alveolar and Long Bone Remodeling to Explore OTM Model Potential

Author Spotlight: Comparing Alveolar and Long Bone Remodeling to Explore OTM Model Potential

Published on: July 21, 2023

The microbiota-gut-bone axis and bone health.

Ye Tu^1,2, Ran Yang^1,3, Xin Xu^1,2

¹State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, P.R. China.

Journal of Leukocyte Biology

|April 22, 2021

Summary

The gut microbiota influences bone health by affecting metabolism and immunity. Microbiota-targeting therapies like probiotics show promise for preventing bone loss, but more clinical trials are needed.

Keywords:

bone metabolism gut microbiota osteoimmunology osteoporosis probiotics

More Related Videos

Author Spotlight: An Economic and Efficient Method for Quantitative Evaluation of Bone Microarchitecture in a Murine Osteoporosis Model

Author Spotlight: An Economic and Efficient Method for Quantitative Evaluation of Bone Microarchitecture in a Murine Osteoporosis Model

Published on: September 8, 2023

Author Spotlight: Enhancing Small Animal Bone Compression Testing for Research

Author Spotlight: Enhancing Small Animal Bone Compression Testing for Research

Published on: December 1, 2023

Related Experiment Videos

Last Updated: Nov 8, 2025

Author Spotlight: Comparing Alveolar and Long Bone Remodeling to Explore OTM Model Potential

Author Spotlight: Comparing Alveolar and Long Bone Remodeling to Explore OTM Model Potential

Published on: July 21, 2023

Author Spotlight: An Economic and Efficient Method for Quantitative Evaluation of Bone Microarchitecture in a Murine Osteoporosis Model

Author Spotlight: An Economic and Efficient Method for Quantitative Evaluation of Bone Microarchitecture in a Murine Osteoporosis Model

Published on: September 8, 2023

Author Spotlight: Enhancing Small Animal Bone Compression Testing for Research

Author Spotlight: Enhancing Small Animal Bone Compression Testing for Research

Published on: December 1, 2023

Area of Science:

Microbiology
Gastroenterology
Orthopedics

Background:

The human gastrointestinal tract hosts trillions of microorganisms, termed the "second gene pool."
The microbiota-gut-bone axis is increasingly recognized for its role in skeletal health.
Gut microbial dysbiosis is implicated in various bone disorders.

Purpose of the Study:

To explore the connection between gut microbiota and skeletal homeostasis.
To review the mechanisms by which gut microbiota influences bone health.
To assess the potential of microbiota-targeting therapies for bone disorders.

Main Methods:

Literature review of studies on gut microbiota and bone health.
Analysis of the role of gut microbiota in host metabolism, immune function, and hormonal secretion.
Evaluation of evidence for probiotics and prebiotics in preventing bone loss.

Main Results:

Gut microbiota significantly regulates skeletal homeostasis.
Dysbiosis is linked to multiple bone disorders.
Probiotics and prebiotics demonstrate efficacy in preventing bone loss in some studies.

Conclusions:

The gut microbiota plays a critical role in maintaining skeletal health.
Targeting the gut microbiota offers a novel therapeutic strategy for bone disorders.
Further well-controlled clinical trials are necessary to confirm the long-term efficacy and safety of these interventions.