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Updated: Nov 8, 2025

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Copper nanoclusters: designed synthesis, structural diversity, and multiplatform applications.

Ani Baghdasaryan1, Thomas Bürgi

  • 1Department of Physical Chemistry, University of Geneva, 30 Quai Ernest-Ansermet, 1211 Geneva 4, Switzerland. thomas.buergi@unige.ch.

Nanoscale
|April 22, 2021
PubMed
Summary

Atomically precise metal nanoclusters (MNCs), particularly copper nanoclusters (CuNCs), exhibit unique molecular-like properties. Ongoing research focuses on their potential in catalysis and biomedical applications, despite existing challenges.

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Area of Science:

  • Nanomaterials Science
  • Inorganic Chemistry
  • Catalysis
  • Biomedical Engineering

Background:

  • Atomically precise metal nanoclusters (MNCs) possess unique properties due to quantized electronic states.
  • Monolayer-protected metal nanoclusters, especially copper (CuNCs), are a relatively new field with significant progress.
  • These nanoclusters offer diverse molecular-like absorption, luminescence, and magnetic characteristics.

Purpose of the Study:

  • To review the achievements and challenges in the field of copper nanoclusters (CuNCs).
  • To highlight the potential of CuNCs in catalysis and biomedical applications.
  • To guide researchers toward a deeper understanding and design of novel CuNC-based materials.

Main Methods:

  • Literature review of recent advancements in CuNC synthesis and characterization.

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  • Analysis of studies focusing on catalytic applications of CuNCs.
  • Survey of research on biomedical applications, including diagnostics and therapeutics.

    • Main Results:

    • CuNCs demonstrate high efficiency and activity as catalysts for chemical conversions.
    • CuNCs show promise as fluorescent contrast agents and therapeutic agents for disease treatment and early diagnosis.
    • A substantial library of atomically precise CuNC structures has been developed.

    Conclusions:

    • CuNCs are promising nanomaterials with significant potential in catalysis and biomedicine.
    • Further interdisciplinary research is needed to fully understand and exploit their unique properties.
    • Overcoming current challenges will enable the design of advanced, stable CuNC-based catalysts, biosensors, and therapeutic agents.