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Arena3Dweb: interactive 3D visualization of multilayered networks.

Evangelos Karatzas1, Fotis A Baltoumas1, Nikolaos A Panayiotou2

  • 1Institute for Fundamental Biomedical Research, BSRC "Alexander Fleming", Vari, Greece.

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Summary
This summary is machine-generated.

Arena3Dweb offers interactive 3D visualization for complex biomedical networks. This web application integrates multiple networks, enabling enhanced analysis of biological pathways and drug repurposing for diseases like SARS-CoV-2.

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Area of Science:

  • Bioinformatics
  • Computational Biology
  • Data Visualization

Background:

  • Integrating heterogeneous biomedical data is challenging.
  • Visualizing complex, multilayered networks requires advanced tools.

Purpose of the Study:

  • Introduce Arena3Dweb, a novel, interactive, web-based 3D graph visualization application.
  • Enable seamless integration and visualization of multiple, interconnected biomedical networks.

Main Methods:

  • Developed a dependency-free web application using R, Shiny, and JavaScript.
  • Implemented interactive 3D visualization for multilayered graphs.
  • Included various layout algorithms, network alignment, and dynamic adjustments for nodes and edges.

Main Results:

  • Arena3Dweb allows users to integrate and visualize multiple networks in 3D space with intra- and inter-layer connections.
  • Users can customize views using diverse layout algorithms, network alignment, and on-the-fly adjustments.
  • Demonstrated utility through use cases in SARS-CoV-2 drug repurposing and GPCR signaling pathways in melanoma.

Conclusions:

  • Arena3Dweb provides an effective solution for visualizing complex biomedical data.
  • The application facilitates exploration of biological networks for research areas like drug discovery and pathway analysis.