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Dynamic Multiparameter Platelet Function Assessment Using a Capacitive Biosensor
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Dynamic Multiparameter Platelet Function Assessment Using a Capacitive Biosensor

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Impact of electric cardioversion on platelet activation

Harald Haidl1, Johanna Gaugler1, Gerhard Cvirn2

  • 1Division of General Paediatrics, Department of Paediatrics and Adolescent Medicine, Medical University of Graz, Graz, Austria.

Plos One
|April 22, 2021
PubMed

Insights

Electric cardioversion (EC) does not increase platelet activation or blood clotting risk in atrial fibrillation (AF) patients. This study found no significant changes in platelet markers after EC, suggesting it is safe for AF management.

Area of Science:

  • Cardiology
  • Hematology

Background:

  • Atrial fibrillation (AF) significantly increases stroke risk, persisting even after rhythm restoration.
  • Evaluating the impact of cardioversion on thrombotic risk factors is crucial for patient management.

Purpose of the Study:

  • To assess the effect of electric cardioversion (EC) on platelet activation and procoagulatory tendency in patients with AF.

Main Methods:

  • Platelet activation was measured using flow cytometry and Multiplate® impedance aggregometry.
  • Serum levels of platelet factor 4 (PF4) and ß-thromboglobulin (ß-TG) were quantified.
  • Measurements were taken before and after EC in 10 AF patients.

Main Results:

  • No significant changes were observed in P-selectin expression or integrin αIIbβ3 activation post-EC.
  • Serum levels of PF4 and ß-TG remained stable before and after the procedure.
  • Platelet aggregation assays showed no significant alterations after EC.

Conclusions:

  • Electric cardioversion does not appear to influence platelet activation markers or procoagulatory tendency.
  • These findings support the safety of EC in AF patients regarding thrombotic risk.
Abstract

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