Association between Serum Serglycin Levels and St-Segment Elevation Myocardial Infarction
Burcu Ugurlu Ilgın1, Emrullah Kızıltunç1, Murat Gök2
1TC Saglık Bakanlıgı Gazi Mustafa Kemal Devlet Hastanesi - Cardiology, Ankara - Turquia.
Arquivos Brasileiros De Cardiologia
|April 22, 2021
Summary
Serum serglycin levels are significantly elevated in patients with ST-segment elevation myocardial infarction (STEMI). Higher serglycin indicates increased risk and correlates with inflammation and infarct size markers.
Area of Science:
- Cardiology
- Biochemistry
- Biomarkers
Background:
- Serglycin plays roles in fibrin stabilization and inflammation.
- Limited data exists on serglycin's clinical significance in atherosclerotic heart disease.
Purpose of the Study:
- To measure serum serglycin levels in acute myocardial infarction (AMI) patients.
- To examine the relationship between serglycin levels and markers of inflammation and infarct size.
Main Methods:
- Compared serum serglycin levels in 75 ST-segment elevation myocardial infarction (STEMI) patients and 57 normal coronary artery (NCA) controls.
- Recorded patient characteristics, serum serglycin, high-sensitivity C-reactive protein (hs-CRP), and peak troponin T levels.
Main Results:
- STEMI patients had significantly higher serum serglycin levels than controls (102.81±39.42 vs. 57.13±32.25, p<0.001).
- Serglycin positively correlated with troponin (p<0.001) and hs-CRP (p<0.001).
- Serum serglycin independently predicted STEMI with 75.7% sensitivity and 68.4% specificity at a cutoff of 80.47 μg/L.
Conclusions:
- Serum serglycin levels are elevated in STEMI patients.
- Serglycin levels correlate positively with inflammation and infarct size markers.
- Serglycin is a potential independent biomarker for STEMI.
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