[Mechanism of the development of epidural analgesia using opiates and anesthetics]

A special model was used in order to investigate the morphine and dikain permeability of dura mater (DM) in 33 people after sudden death at the age of from 20 to 79. The morphine permeability of spinal DM was found to be 20.5% greater than that of the root DM, while the dikain permeability was 28.5% greater irrespective of the age. The quantitative evaluation of perineural diffusion of morphine and dikain is first given along the pathway of dorsal and ventral roots. A conclusion was made that the perineural pathway of spread of opiates and local anesthetics is of great significance in the mechanism of development of this kind of anesthesia.