Different reorganizations of functional brain networks after first-ever and recurrent ischemic stroke

Even though recurrent stroke patients constitute a large percentage of the stroke population, few studies specifically investigated their neural reorganization. In this study, we recruited seventeen first-ever stroke patients as well as fourteen recurrent stroke patients, and recorded their resting EEG signals and NIHSS score before and after two weeks of recovery, to compare their neural reorganization from network scale. The clinical improvements were comparable in two groups during the two weeks. However, their brain networks were differently reorganized, especially in the delta band. The recurrent stroke patients showed an increased clustering coefficient and a decreased characteristic path length of the delta network, along with increased ipsilesional intrahemispheric connectivity; while no such changes were observed in the first-ever stroke patients. Our results suggest that stroke history influences neural reorganization during recovery.