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Related Concept Videos

The Tumor Microenvironment02:17

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Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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Related Experiment Video

Updated: Nov 8, 2025

Inducing Targeted Mild Hyperthermia in Murine Tumor Models through Photothermal Conversion of Near-infrared Light by Intratumoral Gold Nanorods
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Inflammatory microenvironment-targeted nanotherapies.

Guangshuai Zhang1, Lixue Ma1, Lijun Bai1

  • 1Wuya College of Innovation, Shenyang Pharmaceutical University, No. 103, Wenhua Road, Shenyang 110016, China.

Journal of Controlled Release : Official Journal of the Controlled Release Society
|April 22, 2021
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Summary
This summary is machine-generated.

Inflammatory microenvironments drive chronic diseases. Targeting these with nanotherapies offers improved treatment for inflammatory diseases with fewer side effects.

Keywords:
Chronic diseasesInflammatory microenvironmentsNanotherapies

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Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Immunology

Background:

  • Inflammatory microenvironments (IMEs) are key pathological features implicated in chronic disease progression.
  • Targeting IMEs presents a promising therapeutic strategy for managing inflammatory conditions.

Purpose of the Study:

  • To review the role of IMEs in disease pathogenesis.
  • To discuss the application and potential of nanotherapies specifically designed to target IMEs for treating inflammatory diseases.

Main Methods:

  • Literature review focusing on IME-targeted nanotherapies.
  • Analysis of current research on nanoplatforms for anti-inflammatory treatments.
  • Discussion of rational targeting strategies for IMEs.

Main Results:

  • Nanoplatforms enhance the efficiency of anti-inflammatory treatments.
  • IME-targeted nanotherapies demonstrate improved therapeutic effects and reduced side effects.
  • Strategic targeting of IMEs in damaged tissues is crucial for effective therapy.

Conclusions:

  • IME-targeted nanotherapies are a rapidly developing area with significant potential for treating chronic inflammatory diseases.
  • Further development of rational targeting strategies is essential for optimizing therapeutic outcomes.