Related Experiment Video
Updated: Nov 8, 2025

07:48
Tracking Drug-induced Changes in Receptor Post-internalization Trafficking by Colocalizational Analysis
Published on: July 3, 2015
9.0K
Getting there: Thyroid hormone receptor intracellular trafficking
1Department of Biology, William & Mary, Williamsburg, Virginia, USA.
The Journal of Biological Chemistry
|April 22, 2021
Summary
This article reviews nuclear receptor research, focusing on thyroid hormone receptor trafficking. It also shares personal reflections on being a woman in STEM and promoting inclusivity in science.
Area of Science:
- Molecular Biology
- Endocrinology
- Cell Biology
Background:
- The study's context is set against global events like the COVID-19 pandemic and social movements.
- The author reflects on personal experiences as a woman in STEM.
- The narrative intertwines scientific progress with a personal journey of inclusivity.
Purpose of the Study:
- To review contributions to nuclear receptor research, specifically the thyroid hormone receptor.
- To highlight the importance of intentional inclusivity in scientific communities.
- To encourage young scientists, particularly women, to pursue careers in STEM.
Main Methods:
- The article discusses milestones in understanding the intracellular trafficking of the thyroid hormone receptor.
- It employs a narrative approach, blending scientific review with personal reflections.
- The author shares experiences related to mentorship and fostering an inclusive lab environment.
Main Results:
- Key advancements in thyroid hormone receptor intracellular trafficking are presented.
- The narrative emphasizes the challenges and rewards of a career in science.
- The importance of diversity and inclusion in scientific research is underscored.
Conclusions:
- The author's journey illustrates the integration of scientific inquiry with personal and social contexts.
- Fostering an inclusive environment is crucial for scientific progress and mentorship.
- The article serves as an encouragement for aspiring scientists to persevere in their chosen fields.
More Related Videos
Related Concept Videos
Intracellular Hormone Receptors
57.4K
Lipid-soluble hormones diffuse across the plasma and nuclear membrane of target cells to bind to their specific intracellular receptors. These receptors act as transcription factors that regulate gene expression and protein synthesis in the target cell
57.4K
Synthesis and Regulation of Thyroid Hormones
6.1K
Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
6.1K
Internal Receptors
72.7K
Many cellular signals are hydrophilic and therefore cannot pass through the plasma membrane. However, small or hydrophobic signaling molecules can cross the hydrophobic core of the plasma membrane and bind to internal, or intracellular, receptors that reside within the cell. Many mammalian steroid hormones use this mechanism of cell signaling, as does nitric oxide (NO) gas.
72.7K
Types of Receptors: Internal Receptors
29.2K
Many cellular signals are hydrophilic and cannot pass through the plasma membrane. However, small or hydrophobic signaling molecules can cross the hydrophobic core of the plasma membrane and bind intracellular receptors that reside within the cell cytoplasm or nucleus. Many mammalian steroid hormones and nitric oxide (NO) gas use this cell signaling mechanism.
Similar to membrane-bound receptors, the binding of a ligand to the intracellular receptor of causes a conformational change in the...
Similar to membrane-bound receptors, the binding of a ligand to the intracellular receptor of causes a conformational change in the...
29.2K
Receptor-mediated Endocytosis
7.0K
Receptor-mediated endocytosis is when bulk amounts of specific molecules are imported into a cell after binding to cell surface receptors. The molecules bound to these receptors are taken into the cell through inward folding of the cell surface membrane, which is eventually pinched off into a vesicle within the cell. Structural proteins, such as clathrin, coat the budding vesicle.
Clathrin-Mediated Endocytosis of LDL
One well-characterized example of receptor-mediated endocytosis is the...
Clathrin-Mediated Endocytosis of LDL
One well-characterized example of receptor-mediated endocytosis is the...
7.0K
Receptor-mediated Endocytosis
108.4K
Overview
108.4K

