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Cerebral Venous Thrombosis in COVID-19: A New York Metropolitan Cohort Study

F Al-Mufti1,2, K Amuluru3, R Sahni4,2

  • 1From the Departments of Neurosurgery (F.A.-M., R.S., J.C., P.O., R.N., J.F.D., T.S., E.G., S.A.M., C.G.) Fawaz.Al-Mufti@wmchealth.org.

AJNR. American Journal of Neuroradiology
|April 23, 2021
PubMed

Insights

Patients hospitalized with COVID-19 showed a higher incidence of cerebral venous thrombosis (CVT). CVT should be considered in patients with COVID-19 presenting with neurological symptoms.

Area of Science:

  • Neurology
  • Infectious Diseases
  • Vascular Medicine

Background:

  • Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) infection is linked to hypercoagulability.
  • COVID-19 patients exhibit an increased risk for thrombotic events.

Purpose of the Study:

  • To evaluate the demographic and clinical characteristics of cerebral venous thrombosis (CVT) in hospitalized COVID-19 patients.
  • To determine the incidence of CVT in a large cohort of COVID-19 patients.

Main Methods:

  • Retrospective multicenter cohort study.
  • Inclusion of 13,500 consecutive patients hospitalized with COVID-19.
  • Data collection from March 1 to May 30, 2020, across 6 tertiary care centers.

Main Results:

  • Twelve patients (0.09%) were diagnosed with imaging-proved CVT, an incidence of 8.8 per 10,000 over 3 months.
  • This incidence is significantly higher than the general population's annual incidence (5 per million).
  • Neurologic symptoms preceded CVT diagnosis in 58% of cases; 75% had venous infarction or hemorrhage.

Conclusions:

  • Hospitalized COVID-19 patients demonstrate a higher-than-expected frequency of cerebral venous thrombosis.
  • Cerebral venous thrombosis should be considered in the differential diagnosis for neurologic syndromes in SARS-CoV-2 infected individuals.
Abstract

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