A short review on cell-based biosensing: challenges and breakthroughs in biomedical analysis

Area of Science:

• Biomedical engineering
• Synthetic biology
• Cellular biosensing

Background:

• Cell-based biosensors have evolved beyond simple alternatives to molecular bioreceptors.
• They now serve as crucial interfaces between biological systems and microelectronics.
• Recent advancements focus on mammalian cells for novel sensing and theranostic platforms.

Purpose of the Study:

• To review recent literature on whole-cell biosensors, emphasizing mammalian cell applications.
• To highlight challenges and breakthroughs in biomedical analyses using novel biosensing concepts.
• To explore the potential of synthetic biology in advancing cell-based biosensor technology.

Main Methods:

• Review of current scientific literature on whole-cell biosensors.
• Emphasis on studies utilizing mammalian cells.
• Analysis of synthetic biology tools and novel biosensing concepts.

Main Results:

• Cell-based biosensing platforms now offer tailored performance characteristics.
• Achieved levels of sensitivity, dynamic range, and stability are suitable for medical relevance.
• Innovations enable flexible biosensing platforms for research and clinical use.

Conclusions:

• Recent advancements in whole-cell biosensors facilitate development of highly sensitive and stable platforms.
• These platforms bridge molecular biology with microelectronics for diverse applications.
• The work aims to promote the generation and adoption of advanced cell-based biosensors.