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Experimental therapies under investigation for COVID-19

Reshma Golamari1, Neeru Kapoor2, Tanuja Devaraj1

  • 1Assistant Professor of Medicine, Penn State Health Milton S. Hershey Medical Center, Hershey, PA, USA.

Journal of Community Hospital Internal Medicine Perspectives
|April 23, 2021
PubMed

Insights

This review summarizes COVID-19 treatments, highlighting the urgent need for effective therapies against SARS-CoV-2. Many options are under investigation, with supportive care remaining crucial for patients with Coronavirus Disease 2019.

Area of Science:

  • Virology
  • Infectious Diseases
  • Public Health

Background:

  • Coronavirus Disease 2019 (COVID-19), caused by SARS-CoV-2, emerged in Wuhan, China, leading to a global pandemic with over 1.7 million deaths by December 2020.
  • The disease presents with varied patient effects, from asymptomatic cases to critical illness requiring intensive care.

Purpose of the Study:

  • To review and summarize the diverse treatment options investigated for COVID-19.
  • To discuss the potential mechanisms of action for antiviral therapies targeting SARS-CoV-2.

Main Methods:

  • Literature review of clinical trials and small-scale studies on COVID-19 treatments.
  • Analysis of reported efficacy and mechanisms of action for various therapeutic interventions.

Main Results:

  • Few treatments have demonstrated definitive efficacy, necessitating continued research and development.
  • Supportive care remains a cornerstone of managing COVID-19 patients.

Conclusions:

  • The development of effective treatments and vaccines for COVID-19 is a critical global health priority.
  • Understanding the mechanisms of antiviral action is key to combating the SARS-CoV-2 pandemic.
Keywords:
COVID-19 treatmenthydroxychloroquinepandemic drugsremdesivirtherapies for COVID-19

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