Acute onset of blisters in an infant with acrodermatitis enteropathica: A case report

Area of Science:

• Pediatric Dermatology
• Nutritional Disorders
• Genetic Diseases

Background:

• Acrodermatitis enteropathica (AE) is a rare autosomal recessive disorder caused by impaired zinc absorption.
• It typically manifests in early infancy, often after breastfeeding cessation.
• Cutaneous symptoms are characteristic but can vary in presentation.

Observation:

• This report details a pediatric case of AE presenting with acute-onset blistering in infancy.
• Blisters, while a known feature, are not always prominent and may be overlooked.
• The case highlights the importance of considering AE in the differential diagnosis of acute blistering disorders in infants.

Findings:

• Acrodermatitis enteropathica can present with acute blistering, mimicking other infantile dermatoses.
• A comprehensive differential diagnosis for infantile blistering is essential for timely recognition.
• Lifelong zinc supplementation is the cornerstone of AE management.

Implications:

• Increased awareness of AE's varied cutaneous presentations can improve diagnostic accuracy.
• Prompt identification and treatment of AE prevent severe morbidity associated with zinc deficiency.
• This case underscores the critical role of pediatricians and dermatologists in recognizing and managing genetic malabsorption syndromes.