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Related Concept Videos

Bone Disorders01:29

Bone Disorders

4.8K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
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The Functions of the Skeletal System01:22

The Functions of the Skeletal System

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The most apparent functions of the skeletal system are support, protection, and movement. However, bone tissue also performs several other critical metabolic functions. For one, the bone matrix acts as a reservoir for a number of minerals important to the functioning of the body, especially calcium and phosphorus. These minerals, present in the bone tissue, can be released back into the bloodstream when required. Calcium ions, for example, are essential for muscle contractions and controlling...
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Disorders of the Skeletal Muscle01:28

Disorders of the Skeletal Muscle

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The clinical conditions affecting the skeletal muscle tissue are broadly categorized as musculoskeletal and neuromuscular disorders.
Musculoskeletal disorders
Musculoskeletal disorders involve injuries and conditions affecting the skeletal muscles and associated connective tissues. These disorders can arise from acute biomechanical stresses or chronic overuse and can occur across different age groups. Common injuries include sprains, fractures, and muscular strains, often resulting from...
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Bone Formation by Intramembranous Ossification01:29

Bone Formation by Intramembranous Ossification

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Intramembranous ossification is one of the two processes involved in the development of bones within an embryo. The flat bones of the face, most of the cranial bones, and the clavicles are formed via this process. During intramembranous ossification, the bones develop directly from sheets of undifferentiated mesenchymal connective tissue.
The process begins when mesenchymal cells in the embryonic skeleton gather together and differentiate into osteogenic cells, which then develop into ...
9.0K
Fractures: Bone Repair01:27

Fractures: Bone Repair

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Treatment for a fracture is based on the type of break, the bone affected, and the patient's age.
Minor fractures with no bone displacement are treated by immobilizing the fractured bone using a cast or splint. However, in the case of fractures with displaced bones, the broken bones are repositioned before immobilization to ensure successful healing without deformation and loss of function. The realignment of fractured bone ends is performed through a process called reduction. If the...
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What is the Skeletal System?01:02

What is the Skeletal System?

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Overview
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Related Experiment Video

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Scanning Skeletal Remains for Bone Mineral Density in Forensic Contexts
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Scanning Skeletal Remains for Bone Mineral Density in Forensic Contexts

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Neonatal Bone Disorders.

Vrinda Saraff1,2, Ruchi Nadar2, Nick Shaw2,3

  • 1Institute of Applied Health Research, University of Birmingham, Birmingham, United Kingdom.

Frontiers in Pediatrics
|April 23, 2021
PubMed
Summary
This summary is machine-generated.

Neonatologists diagnose and manage neonatal bone disorders. Early diagnosis through advanced imaging and molecular testing is crucial for timely, life-saving treatment in newborns with suspected skeletal conditions.

Keywords:
antenatalbonemineralizationnewbornstructural

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Area of Science:

  • Pediatrics
  • Neonatology
  • Skeletal Dysplasias

Background:

  • Neonatal bone diseases require specialized care from neonatologists.
  • Advances in ultrasound enable earlier detection of fetal bone abnormalities.
  • Accurate diagnosis is essential for timely intervention in critical neonatal conditions.

Purpose of the Study:

  • To present a diagnostic and management strategy for neonates with suspected bone disorders.
  • To highlight the importance of prompt diagnosis for effective treatment.
  • To guide neonatologists in investigating antenatal and postnatal findings.

Main Methods:

  • Review of diagnostic approaches for neonatal bone disorders.
  • Emphasis on utilizing advanced imaging (ultrasound) and molecular testing.
  • Outline of a structured investigation pathway.

Main Results:

  • Improved antenatal detection necessitates further postnatal diagnostic evaluation.
  • Molecular testing aids in confirming diagnoses and guiding management.
  • A systematic approach ensures comprehensive care for affected newborns.

Conclusions:

  • Early and accurate diagnosis of neonatal bone disorders is critical.
  • Multidisciplinary approach involving neonatologists and specialists is key.
  • Timely intervention based on confirmed diagnosis can be life-saving.