Related Experiment Video
Updated: Nov 8, 2025
Cutoff Value of Phase Angle by Bioelectrical Impedance Analysis at Admission as a Prognostic Factor in Patients with Acute Heart Failure
Published on: June 10, 2025
Dietary Inflammatory Index Is Related to Heart Failure Risk and Cardiac Function: A Case-Control Study in Heart
Jalal Moludi1,2, Nitin Shivappa3,4,5, Soghra Alisgharzadeh6
1School of Nutrition Sciences and Food Technology, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Insights
A higher Dietary Inflammatory Index (DII) score, indicating a more inflammatory diet, is linked to an increased risk of heart failure (HF). Reducing DII scores through dietary changes may help prevent HF and improve patient outcomes.
Area of Science:
- Cardiology
- Nutrition Science
- Inflammation Research
Background:
- Diet and inflammation are recognized risk factors for heart failure (HF).
- The Dietary Inflammatory Index (DII) quantifies the inflammatory potential of an individual's diet.
- Previous research has not fully elucidated the association between DII and HF risk.
Purpose of the Study:
- To investigate the association between Dietary Inflammatory Index (DII) scores and heart failure (HF) in a case-control study.
- To compare DII scores between HF patients and healthy controls.
- To explore the relationship between DII, NT-proBNP levels, and left ventricular ejection fraction (LVEF) in HF patients.
Main Methods:
- A case-control study involving 116 HF cases and 113 controls.
- Calculation of DII scores based on individual dietary intake.
- Assessment of N-Terminal pro-brain natriuretic peptide (NT-proBNP) and ejection fraction (EF).
- Conditional logistic regression for DII and HF risk; linear regression for DII and LVEF.
Main Results:
- A statistically significant difference in DII scores was observed between HF cases and controls (p=0.040).
- Higher DII scores were associated with an increased risk of HF (OR: 1.30; p=0.047).
- Elevated DII scores correlated with higher NT-proBNP levels and lower ejection fraction (EF).
- Inverse association found between EF and saturated fatty acid intake (p=0.012).
Conclusions:
- The Dietary Inflammatory Index (DII) is significantly associated with a higher probability of developing heart failure (HF).
- Consuming an anti-inflammatory diet, reflected by lower DII scores, may contribute to HF prevention.
- Dietary modification to reduce DII scores represents a potential strategy for improving clinical outcomes in HF patients.
Abstract:
Aims: Previous studies suggest that diet and inflammation are important risk factors for heart failure (HF); however, the associations remain unclear. The Dietary Inflammatory Index (DII®) was established to measure the inflammatory capacity of individuals' diet. This study aimed to explore the DII in HF subjects compared with controls. Methods and Results: We conducted a case-control (116 cases and 113 controls) study that recruited in the similar clinics. DII scores were calculated based on dietary intakes. N-Terminal pro-brain natriuretic peptide (NT-proBNP) levels and ejection fraction (EF) were assessed in both groups. In order to analyze DII scores with HF as the outcome, we used conditional logistic regression. A linear regression was applied to explore the associations between the DII and left ventricular EF (LVEF). There was statistically significant difference in DII scores in cases vs. controls (-0.16 ± 1.37 vs. -0.33 ± 1.67; p = 0.040). Conditional logistic regression has shown that subjects with higher DII scores had higher risk of HF. For every one-point rise in DII score, the odds of having HF increased by 30% (OR: 1.30; CI: 1.03, 1.69; p = 0.047). The EF was inversely associated with saturated fatty acid (β = -0.34, 95% CI: -0.61, -0.07; p = 0.012). Subjects with higher DII scores had higher NT-proBNP levels and had lower EF. Conclusion: The DII score was associated with high probability of HF. It appears that consumption of anti-inflammatory diet may lead to the prevention of HF and therefore suggests that dietary modification with the goal of reducing DII scores could be a valuable strategy for improving clinical outcomes in these patients.
More Related Videos
10:03Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty
Published on: January 28, 2020
04:05Author Spotlight: Unveiling Prognostic Indicators in Heart Failure - The Role of Phase Angle and Bioelectrical Impedance Analysis
Published on: June 30, 2023
Related Concept Videos
01:30Heart Failure IV: Classification and Diagnostic Evaluation
01:27Heart Failure I: Introduction
01:30Heart Failure VII: Nursing Interventions
01:30Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
01:19Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
01:30Coronary Artery Disease I: Introduction