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Related Experiment Video

Updated: Nov 8, 2025

Atomic Force Microscopy Imaging and Force Spectroscopy of Supported Lipid Bilayers
10:15

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Atomic Force Microscopy to Characterize Ginger Lipid-Derived Nanoparticles (GLDNP).

Dingpei Long1, Chunhua Yang1,2, Junsik Sung1

  • 1Institute for Biomedical Sciences, Center for Diagnostics and Therapeutics, Digestive Disease Research Group, Georgia State University, Atlanta, GA, USA.

Bio-Protocol
|April 23, 2021
PubMed
Summary

Ginger-derived nanoparticles (GDNP-2) show potential in treating colitis and colon cancer by targeting the colon. Researchers developed ginger lipid-derived nanoparticles (GLDNP) for targeted drug delivery, visualizing their structure with atomic force microscopy.

Keywords:
6-shogaolAtomic force microscopyColon-targeted drug deliveryGinger lipid-derived nanoparticlesMetabolites of 6-shogaol

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Area of Science:

  • Nanotechnology
  • Gastroenterology
  • Pharmacology

Background:

  • Ginger-derived nanoparticles (GDNP-2) possess therapeutic potential for colon inflammation and cancer.
  • GDNP-2 contains a complex mixture of lipids, proteins, miRNAs, and ginger metabolites.

Purpose of the Study:

  • To develop a well-defined nanocarrier from GDNP-2 lipids.
  • To utilize the nanocarrier for targeted delivery of therapeutic compounds to the colon.
  • To characterize the nanostructure of the developed nanocarrier.

Main Methods:

  • Isolation of lipids from GDNP-2.
  • Self-assembly of lipids into ginger lipid-derived nanoparticles (GLDNP) in aqueous solution.
  • Loading of drug candidates (e.g., 6-shogaol) into GLDNP.
  • Characterization of GLDNP nanostructure using atomic force microscopy (AFM).

Main Results:

  • Ginger lipids self-assembled into GLDNP, a defined nanocarrier.
  • GLDNP successfully delivered drug candidates to the colon.
  • AFM provided detailed visualization of the drug-loaded GLDNP morphology.

Conclusions:

  • GLDNP represents a promising, well-defined nanocarrier for colon-targeted drug delivery.
  • This approach may offer a new strategy for managing colitis and associated colon cancer.
  • The study provides a protocol for GLDNP characterization using AFM.