Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Export of Mitochondrial and Chloroplast Genes02:19

Export of Mitochondrial and Chloroplast Genes

3.9K
A eukaryotic cell can have up to three different types of genetic systems: nuclear, mitochondrial, and chloroplast. During evolution, organelles have exported many genes to the nucleus; this transfer is still ongoing in some plant species. Approximately 18% of the Arabidopsis thaliana nuclear genome is thought to be derived from the chloroplast’s cyanobacterial ancestor, and around 75% of the yeast genome derived from the mitochondria’s bacterial ancestor. This export has occurred...
3.9K
Mitochondrial Precursor Proteins01:39

Mitochondrial Precursor Proteins

3.1K
Mitochondrial precursors are partially unfolded or loosely folded polypeptide chains. Newly synthesized precursors are inhibited from spontaneously folding into their native conformation by the cytosolic chaperones, heat shock proteins 70 (Hsp70), and mitochondrial import stimulation factors (MSFs). Precursors bound to MSFs are guided to the TOM70-TOM37 receptors, while precursors bound to Hsp70  chaperones are targetted to TOM20-TOM22 receptor complexes.
Most of the mitochondrial...
3.1K
Comparing Mitochondrial, Chloroplast, and Prokaryotic Genomes02:16

Comparing Mitochondrial, Chloroplast, and Prokaryotic Genomes

14.6K
The present-day mitochondrial and chloroplast genomes have retained some of the characteristics of their ancestral prokaryotes and also have acquired new attributes during their evolution within eukaryotic cells. Like prokaryotic genomes, mitochondrial and chloroplast genomes neither bind with histone-like proteins nor show complex packaging into chromosome-like structures, as observed in eukaryotes. Unlike mitotic cell divisions observed in eukaryotic cells, mitochondria and chloroplasts...
14.6K
Mitochondrial Membranes01:45

Mitochondrial Membranes

14.4K
A single mitochondrion is a bean-shaped organelle enclosed by a double-membrane system. The outer membrane of mitochondria is smooth and contains many porins - the integral membrane transporters. Porins enable free diffusion of ions and small uncharged molecules through the outer mitochondrial membrane but limit the transport of molecules larger than 5000 Daltons. Further, the outer mitochondrial membrane forms a unique structure called membrane contact sites with other subcellular organelles,...
14.4K
Mitochondria01:37

Mitochondria

17.2K
Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...
17.2K
Mitochondrial Protein Sorting01:39

Mitochondrial Protein Sorting

5.1K
Mitochondria are double-membrane organelles of the eukaryotes involved in cellular metabolism, signaling, ATP synthesis, and programmed cell death.  Each of these processes requires specific proteins and enzymes that must be correctly sorted to the right mitochondrial subcompartment for the proper functioning of the organelle.
Most of these mitochondrial proteins are encoded by the nucleus and imported to the mitochondria as unfolded or loosely folded precursors. Mitochondrial precursors...
5.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Participation of the purinergic P2X7 receptor in molecular complexes in the nucleus of human chondrocytes.

Cellular and molecular life sciences : CMLS·2026
Same author

Deciphering macrophage molecular responses to <i>Porphyromonas gingivalis</i> outer membrane vesicles through combined immunoassay and Raman spectroscopic analyses.

Frontiers in microbiology·2026
Same author

Correction to "Synthesis, Structure, and Properties of CuBiSeCl<sub>2</sub>: A Chalcohalide Material with Low Thermal Conductivity".

Chemistry of materials : a publication of the American Chemical Society·2026
Same author

Mitochondrial dysfunction in cerebrovascular diseases.

Trends in molecular medicine·2026
Same author

Apple derived extracellular vesicles as positive modulators of glial inflammation and gut-brain axis signaling.

Phytomedicine : international journal of phytotherapy and phytopharmacology·2026
Same author

Breast Cancer Risk in over 1.3 Million Women on Antipsychotic Therapy: Life-Saving Drugs or Hidden Trigger for Breast Cancer?

Medical sciences (Basel, Switzerland)·2026
Same journal

Topological skeleton analysis for network-based shape representation in biology and beyond.

iScience·2026
Same journal

Condition-specific neural signatures of reactivation during post-retrieval rest: An EEG study.

iScience·2026
Same journal

Multi-chaotic signal identification employing a causal cross-correlation neural network.

iScience·2026
Same journal

Repeated insertions at positions 261-280 in KPC-2 highlight a ceftazidime-avibactam resistance hotspot.

iScience·2026
Same journal

ROS inhibits microtubule dynamics and cell growth heterogeneity during Arabidopsis sepal morphogenesis.

iScience·2026
Same journal

Type 1 diabetes alters early macrophage-<i>Mycobacterium tuberculosis</i> transcriptional coordination during infection.

iScience·2026
See all related articles

Related Experiment Video

Updated: Nov 8, 2025

A Web Tool for Generating High Quality Machine-readable Biological Pathways
08:01

A Web Tool for Generating High Quality Machine-readable Biological Pathways

Published on: February 8, 2017

18.1K

MitopatHs: a new logically-framed tool for visualizing multiple mitochondrial pathways.

Saverio Marchi1, Marco Zanella2, Paolo Pinton3,4

  • 1Department of Clinical and Molecular Sciences, Marche Polytechnic University, Ancona, Italy.

Iscience
|April 23, 2021
PubMed
Summary
This summary is machine-generated.

MitopatHs is a new tool for exploring human mitochondrial pathways. It offers logical and graphical views to simplify understanding complex molecular routes for researchers.

Keywords:
Cell BiologyMolecular NetworkSoftware

More Related Videos

Author Spotlight: An Optimized Automated Method for Investigating Retinoic Acid Receptors in Neuronal Mitochondria
08:33

Author Spotlight: An Optimized Automated Method for Investigating Retinoic Acid Receptors in Neuronal Mitochondria

Published on: July 28, 2023

765
Visualization and Quantification of Endogenous Intra-Organelle Protein Interactions at ER-Mitochondria Contact Sites by Proximity Ligation Assays
08:27

Visualization and Quantification of Endogenous Intra-Organelle Protein Interactions at ER-Mitochondria Contact Sites by Proximity Ligation Assays

Published on: October 20, 2023

2.0K

Related Experiment Videos

Last Updated: Nov 8, 2025

A Web Tool for Generating High Quality Machine-readable Biological Pathways
08:01

A Web Tool for Generating High Quality Machine-readable Biological Pathways

Published on: February 8, 2017

18.1K
Author Spotlight: An Optimized Automated Method for Investigating Retinoic Acid Receptors in Neuronal Mitochondria
08:33

Author Spotlight: An Optimized Automated Method for Investigating Retinoic Acid Receptors in Neuronal Mitochondria

Published on: July 28, 2023

765
Visualization and Quantification of Endogenous Intra-Organelle Protein Interactions at ER-Mitochondria Contact Sites by Proximity Ligation Assays
08:27

Visualization and Quantification of Endogenous Intra-Organelle Protein Interactions at ER-Mitochondria Contact Sites by Proximity Ligation Assays

Published on: October 20, 2023

2.0K

Area of Science:

  • Cell Biology
  • Biochemistry
  • Bioinformatics

Background:

  • Mitochondria are vital organelles involved in cellular processes like energy metabolism, ion homeostasis, and cell death.
  • Existing databases offer insights into mitochondrial functions, supporting basic and clinical research.
  • Comprehending complex mitochondrial pathways is crucial for advancing biological and medical understanding.

Purpose of the Study:

  • Introduce MitopatHs, a novel web-based dataset for navigating human mitochondrial biochemical signaling pathways.
  • Provide researchers with an accessible tool to visualize and understand intricate molecular routes.
  • Facilitate easier and faster comprehension of mitochondrial pathways for scientific inquiry.

Main Methods:

  • Developed a web-based dataset named MitopatHs.
  • Implemented two complementary visualization methods: a logical view and an intuitive graphical visualization.
  • Ensured the dataset is manually curated, open access, and collaborative.

Main Results:

  • MitopatHs enables navigation among biochemical signaling pathways of human mitochondria.
  • The tool offers a logical view presenting reaction sequences as deductions.
  • An intuitive graphical visualization allows detailed examination of each pathway step.

Conclusions:

  • MitopatHs serves as a valuable, user-friendly resource for studying mitochondrial pathways.
  • The tool's design enhances the visualization and comprehension of complex molecular routes.
  • Its open access and collaborative nature promotes broader scientific engagement and discovery.