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Interfacial interactions between protective, surface-engineered shells and encapsulated bacteria with different cell

Hao Wei1, Xiao-Yu Yang, Wei Geng

  • 1University of Groningen and University Medical Center Groningen, Department of Biomedical Engineering, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands. h.c.van.der.mei@umcg.nl h.j.busscher@umcg.nl.

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Summary
This summary is machine-generated.

Surface-engineered encapsulation protects probiotic bacteria. Weakly interacting yolk-shells and intermediate alginate gels offered the best protection against harsh conditions, unlike strong ZIF-8 shells.

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Area of Science:

  • Biomaterials Science
  • Microbiology
  • Chemical Engineering

Background:

  • Surface-engineered encapsulation protects probiotics from harsh environments.
  • Interfacial interactions between shells and bacteria influence protection efficacy.
  • Probiotic bacteria require protection against gastrointestinal fluids and antibiotics.

Purpose of the Study:

  • To investigate the impact of interfacial interactions on the protective capabilities of different encapsulation methods for probiotic bacteria.
  • To compare the effectiveness of ZIF-8, alginate, and yolk-shell encapsulation strategies for Lactobacillus acidophilus and Bifidobacterium infantis.

Main Methods:

  • Encapsulation of L. acidophilus and B. infantis using ZIF-8 biomineralization (strong interaction), alginate gelation (intermediate interaction), and SiO2 nanoparticle yolk-shell formation (weak interaction).
  • Characterization of bacterial surface properties (charge, composition) and shell porosity.
  • Assessment of protection against simulated gastrointestinal conditions and antibiotic susceptibility.

Main Results:

  • All encapsulation methods produced porous shells.
  • Strongly interacting ZIF-8 shells increased antibiotic susceptibility, potentially due to cell wall damage during biomineralization.
  • Weakly interacting yolk-shells and intermediate alginate gels provided superior protection and maintained probiotic activity.

Conclusions:

  • Interfacial interactions significantly impact the protective efficacy of engineered shells for probiotics.
  • Weakly and intermediately interacting shells are more suitable for protecting probiotic bacteria compared to strongly interacting ones.
  • This research advances the development of effective surface-engineered shells for bacterial protection and application.