Biodegradable Temporizing Matrix Reconstruction of Complex Perineal Burn Wound: A Case Report

Area of Science:

• Regenerative Medicine
• Burn Surgery
• Tissue Engineering

Background:

• Perineal burns pose significant reconstructive challenges due to anatomical complexity and infection risks.
• Elderly, comorbid patients with extensive burns require specialized and reliable treatment options.
• Acute reconstruction of complex perineal burns necessitates advanced wound management strategies.

Observation:

• A 77-year-old male with 42% full-thickness burns, including extensive perineal involvement, was treated.
• Early total burn wound excision was performed, followed by the application of Biodegradable Temporizing Matrix (DTM).
• The matrix demonstrated excellent integration and vascularization despite fecal contamination and multidrug-resistant organism colonization.

Findings:

• The two-stage Biodegradable Temporizing Matrix procedure allowed for successful delamination and serial split-thickness skin autografting.
• Complete and robust graft take was achieved 42 days post-initial matrix application.
• The treatment proved effective even in the presence of an unfavorable local microbial environment.

Implications:

• Biodegradable Temporizing Matrix is a reliable option for reconstructing complex perineal burn wounds in frail elderly patients.
• This approach can restore complex anatomy and function, mitigating risks of infection and contracture.
• The findings support the use of DTM in challenging burn cases, improving patient outcomes.