Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Vesicular Tubular Clusters

Vesicular Tubular Clusters

After budding out from the ER membrane, some COPII vesicles lose their coat and fuse with one another to form larger vesicles and interconnected tubules called vesicular tubular clusters or VTCs. These clusters constitute a compartment at the ER-Golgi interface known as ERGIC (Endoplasmic Reticulum Golgi Intermediate Compartment). The ERGIC is a mobile membrane-bound cargo transport system that sorts proteins secreted from ER and delivers them to the Golgi.
With the help of motor proteins such...

Rab Cascades

Rab Cascades

Rab GTPases act in a regulated cascade during membrane fusion, helping the lipid bilayers mix. The Rab family of proteins are active when bound to GTP, and inactive when bound to GDP. Hence, they act as guanine nucleotide-dependent molecular switches. Rab-GTP recognizes and binds to long or short-range tethering proteins to capture the target vesicle. These tethers coordinate with SNAREs on the vesicle and the target membrane to assemble the trans SNARE complex that locks the mixing bilayers.

Pleiotropy

Pleiotropy

Pleiotropy is the phenomenon in which a single gene impacts multiple, seemingly unrelated phenotypic traits. For example, defects in the SOX10 gene cause Waardenburg Syndrome Type 4, or WS4, which can cause defects in pigmentation, hearing impairments, and an absence of intestinal contractions necessary for elimination. This diversity of phenotypes results from the expression pattern of SOX10 in early embryonic and fetal development. SOX10 is found in neural crest cells that form melanocytes,...

Microtubules in Signaling

Microtubules in Signaling

The primary cilium, made up of microtubules, acts as antennae on the cell surfaces for relaying external stimuli into the cells. These fine hair-like structures are present, generally one per cell. These are non-motile cilia in a 9+0 microtubules arrangement, where the central pair of microtubules are absent. The primary cilia arise from the basal body embedded in the cell membrane. Intraflagellar transport (IFT) carries requisite proteins from the cytoplasm to the cilium because the primary...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Good outcome despite non-occlusive mesenterial ischemia after extracorporeal cardiopulmonary resuscitation, a case report.

Perfusion·2026

Same author

Comparison of double-filtration plasmapheresis (DFPP) versus heparin-mediated extracorporeal LDL-precipitation (HELP)-apheresis in early-onset preeclampsia.

Pregnancy hypertension·2024

Same author

Phenylephrine versus cafedrine/theodrenaline (Akrinor) for the treatment of spinal anaesthesia-induced maternal hypotension during caesarean section: a retrospective single-centre cohort study.

BMJ open·2022

Same author

Standardized Colon Ascendens Stent Peritonitis in Rats - a Simple, Feasible Animal Model to Induce Septic Acute Kidney Injury.

Journal of visualized experiments : JoVE·2022

Same author

Clinical Implication of Phosphodiesterase-4-Inhibition.

International journal of molecular sciences·2022

Same author

Influence of low-flow time on survival after extracorporeal cardiopulmonary resuscitation (eCPR).

Critical care (London, England)·2017

Same journal

[Infection Prevention in the Intensive Care Unit: Evidence-Based Strategies for Reducing Healthcare-Associated Infections].

Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS·2026

Same journal

[Persistent Postoperative Opioid Use].

Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS·2026

Same journal

[Dexamethasone for Perioperative Analgesia].

Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS·2026

Same journal

[Treatment Expectations in the Perioperative Setting - Influence on Postoperative Pain Treatment].

Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS·2026

Same journal

Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS·2026

Same journal

[Correction: Anaesthesiological Concepts in Paediatric Neurosurgery].

Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Nov 8, 2025

Laparoscopy-endoscopy Cooperative Surgery for the Treatment of Gastric Gastrointestinal Stromal Tumors

Laparoscopy-endoscopy Cooperative Surgery for the Treatment of Gastric Gastrointestinal Stromal Tumors

Published on: February 19, 2022

[Sectio Caesarea under Gitelman Syndrome].

Stephan Rombach^1,2, Alexander Benner^1,2, Martin Alexander Schick^1,2

¹Department of Anesthesiology and Critical Care Medical Center, University of Freiburg, Freiburg, Germany.

Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS

|April 23, 2021

Summary

This summary is machine-generated.

Gitelman syndrome, a rare inherited kidney disorder, presents challenges during pregnancy due to electrolyte imbalances. This case highlights anesthetic management for a cesarean delivery in a newly diagnosed patient.

More Related Videos

A Novel Strategy Combining Array-CGH, Whole-exome Sequencing and In Utero Electroporation in Rodents to Identify Causative Genes for Brain Malformations

A Novel Strategy Combining Array-CGH, Whole-exome Sequencing and In Utero Electroporation in Rodents to Identify Causative Genes for Brain Malformations

Published on: December 1, 2017

Full-Endoscopic Surgery for Hypothalamic Hamartoma Resection

Full-Endoscopic Surgery for Hypothalamic Hamartoma Resection

Published on: April 12, 2024

Related Experiment Videos

Last Updated: Nov 8, 2025

Laparoscopy-endoscopy Cooperative Surgery for the Treatment of Gastric Gastrointestinal Stromal Tumors

Laparoscopy-endoscopy Cooperative Surgery for the Treatment of Gastric Gastrointestinal Stromal Tumors

Published on: February 19, 2022

A Novel Strategy Combining Array-CGH, Whole-exome Sequencing and In Utero Electroporation in Rodents to Identify Causative Genes for Brain Malformations

A Novel Strategy Combining Array-CGH, Whole-exome Sequencing and In Utero Electroporation in Rodents to Identify Causative Genes for Brain Malformations

Published on: December 1, 2017

Full-Endoscopic Surgery for Hypothalamic Hamartoma Resection

Full-Endoscopic Surgery for Hypothalamic Hamartoma Resection

Published on: April 12, 2024

Area of Science:

Nephrology
Genetics
Obstetrics

Background:

Gitelman syndrome is a rare inherited renal tubulopathy.
It is characterized by hypokalemia, hypomagnesemia, and metabolic alkalosis.
Caused by SLC12A3 gene mutations affecting ion transport in distal tubules.

Observation:

Few reports exist on pregnant women with Gitelman syndrome.
Pregnancy management and outcomes for these patients remain largely unaddressed.
A case of primary cesarean delivery in a 22-year-old woman with newly diagnosed Gitelman syndrome is presented.

Findings:

The study focuses on the anesthesiological approach for cesarean delivery in a pregnant patient with Gitelman syndrome.
It addresses the complexities of managing electrolyte imbalances during labor and delivery.
The case report details the specific anesthetic techniques employed.

Implications:

This case provides insights into the obstetric and anesthesiological management of Gitelman syndrome during pregnancy.
It underscores the importance of careful planning for maternal and fetal outcomes.
Further research is needed to establish best practices for managing Gitelman syndrome in pregnant populations.