Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Osmosis and Osmotic Pressure of Solutions

Osmosis and Osmotic Pressure of Solutions

A number of natural and synthetic materials exhibit selective permeation, meaning that only molecules or ions of a certain size, shape, polarity, charge, and so forth, are capable of passing through (permeating) the material. Biological cell membranes provide elegant examples of selective permeation in nature, while dialysis tubing used to remove metabolic wastes from blood is a more simplistic technological example. Regardless of how they may be fabricated, these materials are generally...

Constant Pressure Calorimetry

Constant Pressure Calorimetry

Calorimetry is a technique used to measure the amount of heat involved in a chemical or physical process or to measure the heat transferred to or from a substance. The heat is exchanged with a calibrated and insulated device called the calorimeter. Calorimetry experiments are based on the assumption that there is no heat exchange between the insulated calorimeter and the external environment. The well-insulated calorimeters prevent the transfer of heat between the calorimeter and its external...

Le Chatelier's Principle: Changing Volume (Pressure)

Le Chatelier's Principle: Changing Volume (Pressure)

For gas-phase equilibria, changes in the concentrations of reactants and products can occur with altered volume and pressure. The partial pressure, P, of an ideal gas is proportional to its molar concentration, M.

Pressure of Fluids

Pressure of Fluids

There are many examples of pressure in fluids in everyday life, such as in relation to blood (high or low blood pressure) and in relation to weather (high- and low-pressure weather systems). A given force can have a significantly different effect, depending on the area over which the force is exerted. For instance, a force applied to an area of 1 mm2 has a pressure that is 100 times greater than the same force applied to an area of 1 cm2. That's why a sharp needle is able to poke through...

Concept of Pressure at a Point

Concept of Pressure at a Point

The concept of pressure at a point in a fluid establishes that pressure within a fluid is uniform in all directions at a specific location. This uniformity occurs because fluid molecules exert force evenly across any point due to their random motion and continuous collisions within the fluid. Pressure at a point is determined by the surrounding fluid molecules and is influenced by factors like depth and density, rather than by shape or orientation.
In a fluid at rest, pressure acts equally in...

Responses to Heat and Cold Stress

Responses to Heat and Cold Stress

Every organism has an optimum temperature range within which healthy growth and physiological functioning can occur. At the ends of this range, there will be a minimum and maximum temperature that interrupt biological processes.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Stress-relaxing granular bioprinting materials enable complex and uniform organoid self-organization.

Nature materials·2026

Same author

Glassy adhesion dynamics govern transitions between sub-diffusive and super-diffusive cancer cell migration on viscoelastic substrates.

Nature communications·2026

Same author

Author Correction: Matrix viscoelasticity promotes liver cancer progression in the pre-cirrhotic liver.

Nature·2025

Same author

T Cells Tear Apart Confining Extracellular Matrix Via a Breaststroke-like Motion to Generate Migration Paths.

bioRxiv : the preprint server for biology·2025

Same author

Monocytes use protrusive forces to generate migration paths in viscoelastic collagen-based extracellular matrices.

Proceedings of the National Academy of Sciences of the United States of America·2025

Same author

Substrate stress relaxation regulates monolayer fluidity and leader cell formation for collectively migrating epithelia.

Proceedings of the National Academy of Sciences of the United States of America·2025

Same journal

Arrayed single-gene perturbations identify drivers of human anterior neural tube closure.

eLife·2026

Same journal

Pervasive relaxed selection on spermatogenesis genes coincident with the evolution of polygyny in gorillas.

eLife·2026

Same journal

Impacts of DNA methylation on H2A.Z deposition and nucleosome stability.

eLife·2026

Same journal

Continuous developmental changes in word recognition and language learning across early childhood.

eLife·2026

Same journal

Multiple event segmentation mechanisms in the human brain.

eLife·2026

Same journal

Optimised genome editing for precise DNA insertion and substitution using prime editors in zebrafish.

eLife·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Nov 8, 2025

Mechanostimulation of Multicellular Organisms Through a High-Throughput Microfluidic Compression System

Mechanostimulation of Multicellular Organisms Through a High-Throughput Microfluidic Compression System

Published on: December 23, 2022

Cells under pressure.

Dhiraj Indana¹, Ovijit Chaudhuri¹

¹Department of Mechanical Engineering, Stanford University, Stanford, United States.

|April 23, 2021

Summary

This summary is machine-generated.

Researchers developed a novel technique to apply solid stress to cell aggregates. This method helps uncover how mechanical forces influence cancer cell behavior and progression.

Keywords:

cancer compression extracellular matrix mechanical stress mouse multicellular aggregates physics of living systems tumor

More Related Videos

A Microfluidic Technique to Probe Cell Deformability

A Microfluidic Technique to Probe Cell Deformability

Published on: September 3, 2014

Imaging Leukocyte Adhesion to the Vascular Endothelium at High Intraluminal Pressure

Imaging Leukocyte Adhesion to the Vascular Endothelium at High Intraluminal Pressure

Published on: August 23, 2011

Related Experiment Videos

Last Updated: Nov 8, 2025

Mechanostimulation of Multicellular Organisms Through a High-Throughput Microfluidic Compression System

Mechanostimulation of Multicellular Organisms Through a High-Throughput Microfluidic Compression System

Published on: December 23, 2022

A Microfluidic Technique to Probe Cell Deformability

A Microfluidic Technique to Probe Cell Deformability

Published on: September 3, 2014

Imaging Leukocyte Adhesion to the Vascular Endothelium at High Intraluminal Pressure

Imaging Leukocyte Adhesion to the Vascular Endothelium at High Intraluminal Pressure

Published on: August 23, 2011

Area of Science:

Biomedical Engineering
Cancer Biology
Cell Mechanics

Background:

Mechanical forces play a crucial role in cellular processes.
Understanding the impact of physical stress on cancer cells is vital for developing new therapies.
Existing methods for applying stress to cell aggregates have limitations.

Purpose of the Study:

To introduce a new method for applying solid stress to cell aggregates.
To investigate the effects of mechanical forces on cancer cell behavior.
To provide insights into the mechanobiology of cancer.

Main Methods:

Development of a novel apparatus for applying controlled solid stress.
Utilizing cell aggregates to mimic tumor microenvironments.
Quantitative analysis of cancer cell responses to mechanical stress.

Main Results:

The new method allows for precise application of solid stress to cell aggregates.
Demonstrated significant impact of mechanical forces on cancer cell morphology and migration.
Observed alterations in cancer cell behavior under varying stress conditions.

Conclusions:

The developed method is effective for studying the role of mechanical forces in cancer.
Mechanical stress is a significant factor influencing cancer cell progression.
This research opens new avenues for understanding and targeting cancer mechanobiology.