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Rosette morphology in zona glomerulosa formation and function.

Sining Leng1, Diana L Carlone1, Nick A Guagliardo2

  • 1Division of Endocrinology, Boston Children's Hospital, Boston, MA, 02115, USA.

Molecular and Cellular Endocrinology
|April 23, 2021
PubMed
Summary
This summary is machine-generated.

The adrenal zona glomerulosa forms compact glomeruli through rosette structures, driven by cell-cell adhesion and basement membrane remodeling. These morphological changes are crucial for adrenal gland function.

Keywords:
Adherent junctionAdrenal cortexAldosteroneCalcium signalingCyp11b2Epithelial remodelingFGFR2GCaMP3MorphogenesisOptopatchRosetteZona fasciculataZona glomerulosaZonal transdifferentiation

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Area of Science:

  • Endocrinology and Cell Biology
  • Adrenal Gland Development and Morphology

Background:

  • Understanding the relationship between morphology and function is key in biology.
  • The adrenal zona glomerulosa (zG) exhibits unique morphological features, including glomeruli and rosettes.

Purpose of the Study:

  • To review the morphological characteristics of the adrenal zona glomerulosa.
  • To highlight recent cellular and molecular discoveries governing zG formation.
  • To discuss the functional implications of zG structures.

Main Methods:

  • Review of existing literature on adrenal zona glomerulosa morphology.
  • Analysis of cellular and molecular mechanisms involved in zG development.
  • Focus on rosette formation and basement membrane composition.

Main Results:

  • The zG comprises glomeruli surrounded by a Laminin-β1-enriched basement membrane.
  • zG cells organize into rosettes via adherens junction-mediated cell constriction.
  • Rosette formation and epithelial folding contribute to the development of adult zG glomeruli.

Conclusions:

  • Adherens junctions and basement membrane remodeling are critical for zG morphogenesis.
  • The formation of rosettes and glomeruli represents a significant developmental process.
  • These morphological adaptations are essential for proper adrenal gland function.