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Subacromial Platelet-Rich Plasma Injections Decrease Pain and Improve Functional Outcomes in Patients With Refractory

Luciano A Rossi1, Nicolás Piuzzi1, Diego Giunta1

  • 1Department of Orthopedics and Traumatology, Prof. Dr. Carlos E. Ottolenghi, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina.

Arthroscopy : the Journal of Arthroscopic & Related Surgery : Official Publication of the Arthroscopy Association of North America and the International Arthroscopy Association
|April 23, 2021
PubMed
Summary

Subacromial platelet-rich plasma (PRP) injections effectively treated refractory rotator cuff tendinopathy, significantly reducing pain and improving function. Most patients experienced resolved sleep issues and returned to their previous sports level.

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Area of Science:

  • Orthopedics
  • Regenerative Medicine
  • Sports Medicine

Background:

  • Rotator cuff tendinopathy is a common cause of shoulder pain and dysfunction.
  • Refractory cases often require advanced treatment options beyond conservative management.
  • Platelet-rich plasma (PRP) is an autologous biological concentrate with potential for tissue healing.

Purpose of the Study:

  • To evaluate the efficacy of subacromial platelet-rich plasma (PRP) injections for patients with refractory rotator cuff tendinopathy.
  • To assess improvements in pain, functional outcomes, sleep quality, and return to sports.
  • To determine the long-term effects of PRP in this patient population.

Main Methods:

  • A prospective cohort study involving 50 patients with refractory rotator cuff tendinopathy.
  • Treatment consisted of a single subacromial injection of leukocyte-rich PRP.
  • Pain was assessed using the Visual Analog Scale (VAS); function with ASES and Constant scores; sleep with the Pittsburgh Sleep Quality Index.

Main Results:

  • Significant improvements were observed in pain (VAS), shoulder function (ASES, Constant scores), and mobility parameters (P < .001).
  • 86% of patients reported resolution of sleep disturbances.
  • 84% of athletes returned to sports, with 78% returning to their pre-injury level.

Conclusions:

  • Subacromial PRP injections are a safe and effective treatment for refractory rotator cuff tendinopathy.
  • PRP therapy leads to significant pain reduction, functional enhancement, and improved sleep quality.
  • The treatment facilitates a successful return to sports for a majority of athletic individuals.