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Related Concept Videos

Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

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In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
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Angle Closure Glaucoma: Treatment01:28

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Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
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Glaucoma: Overview01:25

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Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
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Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption01:22

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As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...
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Blinding is a commonly used method of not telling participants which treatment a subject is receiving. Blinding is a critical part of a randomized control trial or RCT. It reduces the bias that affects the results. In an RCT, blinding is used in the form of a placebo. A placebo effect occurs when untreated subjects falsely believe they have received the treatment and report improved symptoms. A placebo or a dummy treatment is administered to subjects to negate the bias caused by such an effect.
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Related Experiment Video

Updated: Nov 8, 2025

Glaucoma-inducing Procedure in an In Vivo Rat Model and Whole-mount Retina Preparation
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Improved Glaucoma Medication Adherence in a Randomized Controlled Trial.

Kelly W Muir1, Jullia A Rosdahl2, Aaron M Hein3

  • 1Department of Ophthalmology, Duke University School of Medicine, Durham, North Carolina; Durham Center of Innovation to Accelerate Discovery and Practice Transformation, Durham Veterans Affairs Health Care System, Durham, North Carolina.

Ophthalmology. Glaucoma
|April 23, 2021
PubMed
Summary
This summary is machine-generated.

A multifaceted intervention significantly improved glaucoma medication adherence in veterans. The study demonstrated higher adherence rates over six months in the intervention group compared to controls, highlighting the intervention's effectiveness.

Keywords:
AdherenceEducationGlaucoma medication

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Area of Science:

  • Ophthalmology
  • Clinical Trials
  • Health Services Research

Background:

  • Glaucoma medication adherence is critical for preventing vision loss.
  • Poor adherence is a common challenge in managing glaucoma.
  • Effective interventions are needed to improve patient compliance.

Purpose of the Study:

  • To evaluate the effectiveness of a multifaceted intervention aimed at enhancing glaucoma medication adherence.
  • To compare adherence rates between an intervention group and a control group.

Main Methods:

  • A randomized controlled trial was conducted at a Veterans Affairs eye clinic.
  • Participants included veterans with medically treated glaucoma and reported poor adherence.
  • The intervention involved glaucoma education, personalized management suggestions, and a reminder aid.

Main Results:

  • The intervention group showed a significantly higher proportion of prescribed glaucoma medication doses taken on schedule (0.85 vs. 0.62, P < 0.0001).
  • Adherence remained significantly higher in the intervention group throughout the six-month study period.
  • The intervention's effectiveness was consistent across different demographic factors.

Conclusions:

  • A multifaceted intervention strategy can effectively improve medication adherence in glaucoma patients.
  • This approach offers a promising method for enhancing glaucoma management and patient outcomes.