Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Confocal Fluorescence Microscopy

Confocal Fluorescence Microscopy

Confocal microscopy is an advanced microscopic technique. The prime advantage of the confocal microscope over other microscopy techniques is its ability to block the out-of-focus light from the illuminated samples using pinholes. It is widely used with fluorescence optics to obtain high-resolution, sharp contrast images. Unlike optical microscopes, confocal microscopes use a focused beam of light laser to scan the entire sample surface at different z-planes. These microscopes are, therefore,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Thin-Film Eddy Current Sensors for Proximity Detection in Smart Capillary Pick-and-Place.

ACS sensors·2026

Same author

Surface-modified anode current collectors <i>via</i> lithiophilic zinc-based bimetallic co-electrodeposition for lithium-metal batteries.

Nanoscale horizons·2026

Same author

Chemical Mechanical Polishing of Plasma-Modified Cu/Polymer Interfaces for Advanced Hybrid Bonding.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2025

Same author

Nanoporous Capillary Gripper for Ultragentle Micro-Object Manipulation.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2025

Same author

Ultrathin 3D Cu/Li Composite with Enhanced Li Utilization for High Energy Density Li-Metal Battery Anodes.

Small (Weinheim an der Bergstrasse, Germany)·2025

Same author

Nanosecond Laser-Induced Conversion of Leaf-Like Co-MOF to Nanoscale Co@N-gCarbon for Enhanced Multifunctional Electrocatalytic Performance.

ChemSusChem·2025

Same journal

Ultra-Sensitive UV Photodetectors Enabled by Built-in Electric Fields in Hierarchical NP-Type Porous Silicon.

Nanotechnology·2026

Same journal

Effect of sintering temperature on structural, microstructural and magnetic properties of La<sub>0.8</sub>Sr<sub>0.2</sub>MnO<sub>3</sub>: Evolution of faceting and terrace like morphology.

Nanotechnology·2026

Same journal

Engineered V2C MXene Anchored Cu Nanoparticles for Selective Nitrate/Nitrite Sensing and Magneto-Electrocatalytic Hydrogen Evolution Reaction.

Nanotechnology·2026

Same journal

Quantitative Mechanism Separation of Single-Event Transients in Nanosheet Transistors via TCAD Simulation.

Nanotechnology·2026

Same journal

Antibacterial, mechanical and curing properties of PMMA bone cement loaded with copper nanoparticles.

Nanotechnology·2026

Same journal

Deep learning-enabled self-powered bimodal flexible sensor for intelligent access control.

Nanotechnology·2026

See all related articles

Search research articles

Related Experiment Video

Updated: May 31, 2026

Surface Enhanced Raman Spectroscopy Detection of Biomolecules Using EBL Fabricated Nanostructured Substrates

Surface Enhanced Raman Spectroscopy Detection of Biomolecules Using EBL Fabricated Nanostructured Substrates

Published on: March 20, 2015

Exploring SERS from complex patterns fabricated by multi-exposure laser interference lithography.

Seong Jae Kim¹, June Sik Hwang², Jong-Eun Park¹

¹Department of Mechanical Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Republic of Korea.

|April 23, 2021

Summary

This summary is machine-generated.

Multi-exposure laser interference lithography (MELIL) creates uniform plasmonic surfaces for surface-enhanced Raman scattering (SERS) sensors. This cost-effective method offers enhanced performance and tunable optical properties.

Keywords:

laser interference lithography localized surface plasmon resonance surface-enhanced Raman spectroscopy (SERS)

More Related Videos

Determination of the Excitation and Coupling Rates Between Light Emitters and Surface Plasmon Polaritons

Determination of the Excitation and Coupling Rates Between Light Emitters and Surface Plasmon Polaritons

Published on: July 21, 2018

Author Spotlight: Advancements and Applications in Nanoparticle Synthesis Through Laser Ablation in Liquids

Author Spotlight: Advancements and Applications in Nanoparticle Synthesis Through Laser Ablation in Liquids

Published on: June 16, 2023

Related Experiment Videos

Last Updated: May 31, 2026

Surface Enhanced Raman Spectroscopy Detection of Biomolecules Using EBL Fabricated Nanostructured Substrates

Surface Enhanced Raman Spectroscopy Detection of Biomolecules Using EBL Fabricated Nanostructured Substrates

Published on: March 20, 2015

Determination of the Excitation and Coupling Rates Between Light Emitters and Surface Plasmon Polaritons

Determination of the Excitation and Coupling Rates Between Light Emitters and Surface Plasmon Polaritons

Published on: July 21, 2018

Author Spotlight: Advancements and Applications in Nanoparticle Synthesis Through Laser Ablation in Liquids

Author Spotlight: Advancements and Applications in Nanoparticle Synthesis Through Laser Ablation in Liquids

Published on: June 16, 2023

Area of Science:

Plasmonics
Nanotechnology
Surface Science

Background:

Uniform plasmonic surfaces are crucial for reproducible surface-enhanced Raman scattering (SERS) applications.
Periodic nanostructures offer tunable optical properties and uniform SERS response.
Laser interference lithography (LIL) is a maskless technique for fabricating periodic patterns.

Purpose of the Study:

To develop a cost-effective fabrication method for large-area uniform plasmonic surfaces for SERS.
To explore complex interference patterns using multi-exposure laser interference lithography (MELIL).
To evaluate the SERS performance and optical properties of MELIL-fabricated patterns.

Main Methods:

Utilized multi-exposure laser interference lithography (MELIL) to create complex periodic nanostructures.
Deposited gold (Au) via e-beam evaporation and silver (Ag) via electroplating.
Performed quantitative Raman scattering measurements and optical simulations.

Main Results:

Achieved highly uniform SERS with a relative standard deviation below 6% in complex geometries.
Demonstrated significant Raman enhancement factors of 0.387 × 10^5 (Au) and 1.451 × 10^5 (Ag).
Optical simulations revealed broadened and shifted absorption peaks, indicating tunable optical properties.

Conclusions:

MELIL is a versatile and cost-effective method for fabricating uniform plasmonic surfaces for SERS.
Vacuum-free silver electroplating offers enhanced performance and cost-effectiveness.
The MELIL process allows for expanded optical tunability, broadening SERS applications.