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MEGA11: Molecular Evolutionary Genetics Analysis Version 11.

Koichiro Tamura1,2, Glen Stecher3, Sudhir Kumar3,4,5

  • 1Department of Biological Sciences, Tokyo Metropolitan University, Tokyo, Japan.

Molecular Biology and Evolution
|April 23, 2021
PubMed
Summary
This summary is machine-generated.

The updated Molecular Evolutionary Genetics Analysis (MEGA) software now offers advanced tools for constructing evolutionary timetrees and analyzing molecular evolution. These enhancements improve data analysis speed and accuracy for biological discovery.

Keywords:
neutralityphylogeneticssoftwaretimetreestip dating

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Area of Science:

  • Computational molecular evolution
  • Phylogenetics
  • Bioinformatics

Background:

  • The Molecular Evolutionary Genetics Analysis (MEGA) software is a widely used tool for computational molecular evolution.
  • Previous versions provided a collection of methods for phylogenetic analysis.

Purpose of the Study:

  • To introduce new features in MEGA11 that enhance its capabilities for building timetrees and analyzing molecular evolution.
  • To improve the user experience and efficiency of molecular evolutionary analyses.

Main Methods:

  • Implementation of rapid relaxed-clock methods for timetree construction.
  • Integration of probability densities for calibration constraints in node-dating and tip-dating analyses.
  • Addition of Bayesian and machine learning methods for evolutionary probability and rate autocorrelation analyses.

Main Results:

  • Enhanced capabilities for building timetrees of species, pathogens, and gene families.
  • Improved methods for estimating divergence times and confidence intervals using spatiotemporal sampling information.
  • Significant reduction in memory requirements for maximum likelihood analysis and a more responsive graphical user interface for large datasets.

Conclusions:

  • MEGA11 is a more comprehensive and efficient tool for molecular evolutionary analyses.
  • The new features will enhance the user experience, improve the quality of results, and accelerate biological discovery.
  • MEGA11 is available for major operating systems.