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Related Concept Videos

Atherosclerosis II: Clinical Manifestations and Diagnostic Tests01:27

Atherosclerosis II: Clinical Manifestations and Diagnostic Tests

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Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...
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Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation01:21

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Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
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Peripheral Artery Disease I: Introduction01:30

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Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...
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Peripheral Artery Disease (PAD) is characterized by narrowed arteries that diminish blood flow to the extremities. Effective management of PAD requires an interprofessional approach involving various healthcare professionals. The critical aspects of interprofessional care for PAD patients focus on risk factor modification, drug therapy, exercise therapy, nutrition therapy, critical limb ischemia care, and interventional radiology and surgical procedures.The primary treatment goal for PAD...
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Aneurysm II: Clinical Manifestations and Diagnostic Studies01:21

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Thoracic, aortic arch and abdominal aneurysms are significant vascular conditions that can present with various clinical manifestations and lead to serious complications. Understanding these manifestations and the appropriate diagnostic studies is essential for effective management and treatment.Thoracic Aortic AneurysmsThoracic aortic aneurysms often remain asymptomatic until they reach a size that impinges on adjacent structures. They typically cause deep, diffuse chest pain that radiates to...
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Coronary Artery Disease I: Introduction01:30

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Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
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Related Experiment Video

Updated: Nov 8, 2025

Isolation and Excision of Murine Aorta; A Versatile Technique in the Study of Cardiovascular Disease
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Progress in aorta and peripheral cardiovascular disease research.

Lucia Mazzolai1, Adriano Alatri1, Alessandra Bura Rivière2

  • 1Division of Angiology, Heart and Vessel Department, Lausanne University Hospital (CHUV), Lausanne, Switzerland.

Cardiovascular Research
|April 23, 2021
PubMed
Summary

Key 2020 research in vascular diseases includes new insights into aortic aneurysm, fibromuscular dysplasia genetics, and NADPH oxidases. Advances in vulnerable plaque imaging and dual antithrombotic therapy for peripheral artery disease are also highlighted.

Keywords:
AntithromboticsAortaCOVIDPeripheral artery diseaseVenous thromboembolism

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Area of Science:

  • Vascular Biology and Medicine
  • Cardiovascular Research

Background:

  • Despite focus on COVID-19, significant research advanced understanding of aorta and peripheral vascular diseases in 2020.
  • These advancements are poised to impact clinical practice in vascular medicine.

Purpose of the Study:

  • To review key research published in 2020 concerning aorta and peripheral vascular diseases.
  • To highlight novel findings in pathophysiology, diagnostics, and therapeutics for vascular conditions.

Main Methods:

  • Review of significant studies published in 2020 on aortic and peripheral vascular diseases.
  • Synthesis of findings related to pathophysiology, genetics, imaging, and clinical trials.

Main Results:

  • Pathophysiology of aortic aneurysm and dissection suggests kinase inhibitors as potential therapies.
  • Proteogenomic study identified a novel gene for fibromuscular dysplasia (FMD) and a potential blood test.
  • NADPH oxidases' role in endothelial cell differentiation noted, with implications for cell therapy.
  • Magnetic resonance imaging features of vulnerable plaque identified as a stroke risk factor.
  • Clinical trials demonstrated benefits of dual antithrombotic therapy (aspirin plus rivaroxaban) for lower extremity peripheral artery disease.

Conclusions:

  • Recent research offers new therapeutic targets (kinase inhibitors) and diagnostic approaches (FMD blood test) for vascular diseases.
  • Advances in understanding plaque vulnerability and effective treatments for peripheral artery disease are crucial for clinical practice.