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Isolation and Excision of Murine Aorta; A Versatile Technique in the Study of Cardiovascular Disease
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Progress in aorta and peripheral cardiovascular disease research

Lucia Mazzolai1, Adriano Alatri1, Alessandra Bura Rivière2

  • 1Division of Angiology, Heart and Vessel Department, Lausanne University Hospital (CHUV), Lausanne, Switzerland.

Cardiovascular Research
|April 23, 2021
PubMed

Insights

Key 2020 research in vascular diseases includes new insights into aortic aneurysm, fibromuscular dysplasia genetics, and NADPH oxidases. Advances in vulnerable plaque imaging and dual antithrombotic therapy for peripheral artery disease are also highlighted.

Area of Science:

  • Vascular Biology and Medicine
  • Cardiovascular Research

Background:

  • Despite focus on COVID-19, significant research advanced understanding of aorta and peripheral vascular diseases in 2020.
  • These advancements are poised to impact clinical practice in vascular medicine.

Purpose of the Study:

  • To review key research published in 2020 concerning aorta and peripheral vascular diseases.
  • To highlight novel findings in pathophysiology, diagnostics, and therapeutics for vascular conditions.

Main Methods:

  • Review of significant studies published in 2020 on aortic and peripheral vascular diseases.
  • Synthesis of findings related to pathophysiology, genetics, imaging, and clinical trials.

Main Results:

  • Pathophysiology of aortic aneurysm and dissection suggests kinase inhibitors as potential therapies.
  • Proteogenomic study identified a novel gene for fibromuscular dysplasia (FMD) and a potential blood test.
  • NADPH oxidases' role in endothelial cell differentiation noted, with implications for cell therapy.
  • Magnetic resonance imaging features of vulnerable plaque identified as a stroke risk factor.
  • Clinical trials demonstrated benefits of dual antithrombotic therapy (aspirin plus rivaroxaban) for lower extremity peripheral artery disease.

Conclusions:

  • Recent research offers new therapeutic targets (kinase inhibitors) and diagnostic approaches (FMD blood test) for vascular diseases.
  • Advances in understanding plaque vulnerability and effective treatments for peripheral artery disease are crucial for clinical practice.

Keywords:
AntithromboticsAortaCOVIDPeripheral artery diseaseVenous thromboembolism

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