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Related Concept Videos

Alternative RNA Splicing02:18

Alternative RNA Splicing

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Alternative RNA splicing is the regulated splicing of exons and introns to produce different mature mRNAs from a single pre-mRNA. Unlike in constitutive splicing where a single gene produces a single type of mRNA, alternative splicing allows an organism to produce multiple proteins from a single gene and plays an important role in protein diversity.
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Splicing is the process by which eukaryotic RNA is edited before its translation into protein. The RNA strand transcribed from eukaryotic DNA is called the primary transcript. The primary transcripts that become mRNAs are called precursor messenger RNAs (pre-mRNAs). Eukaryotic pre-mRNA contains alternating sequences of exons and introns. Exons are nucleotide sequences that code for proteins, whereas introns are the non-coding regions. In RNA splicing, introns are removed and exons are bonded...
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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
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Exploring the Alternative Splicing of Long Noncoding RNAs.

Muhammad Riaz Khan1, Raymund J Wellinger2, Benoit Laurent1

  • 1Research Center on Aging, Centre Intégré Universitaire de Santé et Services Sociaux de l'Estrie-Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, QC, Canada; Department of Biochemistry and Functional Genomics, Faculty of Medicine and Health Sciences, Université de Sherbrooke, Sherbrooke, QC, Canada.

Trends in Genetics : TIG
|April 24, 2021
PubMed
Summary

Long noncoding RNAs (lncRNAs), like protein-coding genes, undergo splicing to create variants. This review explores lncRNA splicing and its impact on cell biology functions.

Keywords:
alternative splicinglong noncoding RNAsplice variant

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Area of Science:

  • Molecular Biology
  • Genetics
  • Cell Biology

Background:

  • Long noncoding RNAs (lncRNAs) are transcripts longer than 200 nucleotides.
  • lncRNAs play crucial roles in various cellular processes.
  • Similar to protein-coding genes, lncRNAs are transcribed from DNA and contain introns and exons.

Purpose of the Study:

  • To review the current understanding of lncRNA splicing.
  • To discuss the functional implications of lncRNA splice variants in cell biology.

Main Methods:

  • Literature review of studies on lncRNA splicing.
  • Analysis of existing data on lncRNA splice variants.

Main Results:

  • lncRNAs are subject to both constitutive and alternative splicing.
  • Splicing generates diverse lncRNA variants with potentially distinct functions.
  • These variants have significant roles in regulating gene expression and cellular activities.

Conclusions:

  • lncRNA splicing is a key mechanism generating functional diversity.
  • Understanding lncRNA splice variants is essential for comprehending their roles in cell biology.