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Related Experiment Video

Updated: Nov 8, 2025

Cercarial Transformation and in vitro Cultivation of Schistosoma mansoni Schistosomules

Cercarial Transformation and in vitro Cultivation of Schistosoma mansoni Schistosomules

Published on: August 16, 2011

Single-cell deconstruction of stem-cell-driven schistosome development.

Dania Nanes Sarfati¹, Pengyang Li², Alexander J Tarashansky²

¹Department of Biology, Stanford University, Stanford, CA, USA.

Trends in Parasitology

|April 24, 2021

Summary

Schistosomes cause schistosomiasis, a major neglected tropical disease. Understanding their cell types through single-cell transcriptomics offers new strategies to combat this devastating parasitic infection.

Keywords:

cell type atlas development life cycle schistosome single-cell sequencing stem cells

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Published on: January 14, 2018

Area of Science:

Parasitology
Cell Biology
Tropical Medicine

Background:

Schistosomiasis is a severe neglected tropical disease caused by schistosomes.
The parasite has a complex life cycle requiring distinct body plans for host infection and reproduction.
Understanding schistosome cell biology is crucial for disease control.

Purpose of the Study:

To map schistosome cell types using single-cell transcriptomics.
To elucidate the intricate developmental hierarchy of schistosome cells.
To identify potential targets for new therapeutic and preventive strategies.

Main Methods:

Single-cell transcriptomic analysis of multiple schistosome body plans.
Characterization of stem cells and their differentiated progeny.
Analysis of developmental pathways within the parasite.

Main Results:

Comprehensive cell type maps were generated for various schistosome life stages.
Detailed understanding of the cellular and developmental biology of schistosomes was achieved.
Identification of key cell types involved in parasite survival, growth, and reproduction.

Conclusions:

Single-cell transcriptomics provides a powerful tool for schistosome research.
Targeting specific cell type development offers a promising avenue for schistosomiasis intervention.
This research advances basic biology and informs disease control strategies.