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Correlation between Pain Perception and CGRP Expression during Initial Tooth Alignment Using either a Self-ligating

Arief Johanes1, Retno Widayati2, Nurtami Soedarsono3

  • 1Department of Orthodontic, University of Indonesia, Jakarta Pusat, Jakarta, Indonesia.

The Journal of Contemporary Dental Practice
|April 24, 2021
PubMed
Summary
This summary is machine-generated.

Passive self-ligating (PSL) and pre-adjusted edgewise (PE) brackets cause pain and increase calcitonin gene-related peptide (CGRP) during orthodontic tooth movement. The PE group reported higher pain and CGRP levels than the PSL group.

Keywords:
Calcitonin gene-related peptideCohort studyOrthodontic tooth movementPainPassive self-ligating Pre-adjusted.

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Area of Science:

  • Orthodontics
  • Biomarkers
  • Pain Management

Background:

  • Orthodontic tooth movement (OTM) involves inflammation and bone remodeling.
  • Passive self-ligating (PSL) brackets may reduce friction and pain compared to pre-adjusted edgewise (PE) brackets.
  • Calcitonin gene-related peptide (CGRP) in gingival crevicular fluid (GCF) can serve as a pain biomarker for OTM.

Purpose of the Study:

  • To analyze pain perception using the visual analog scale (VAS) and CGRP levels.
  • To investigate the correlation between VAS scores and CGRP levels.
  • To compare pain and CGRP release between PSL and PE bracket systems.

Main Methods:

  • 15 patients were divided into PSL, PE, and control groups.
  • GCF was collected from lower anterior teeth at baseline, 2, 24, and 168 hours post-archwire engagement.
  • Pain was assessed using VAS, and CGRP concentrations were measured via ELISA.

Main Results:

  • VAS scores and CGRP concentrations peaked at 24 hours for both PE and PSL groups.
  • The PE group exhibited higher VAS scores than the PSL group.
  • CGRP levels were highest at 24 hours post-archwire engagement.

Conclusions:

  • Both PSL and PE bracket systems increase pain perception and CGRP levels during initial orthodontic tooth alignment.
  • A weak positive correlation was observed between pain perception scores and CGRP concentrations.
  • Bracket system type influences patient pain perception and CGRP release.