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Serum syndecan-1 reflects organ dysfunction in critically ill patients
Keiko Suzuki1, Hideshi Okada2, Kazuyuki Sumi1
1Department of Pharmacy, Gifu University Hospital, 1-1 Yanagido, Gifu, 501-1194, Japan.
Scientific Reports
|April 24, 2021
Summary
Serum syndecan-1 (SDC-1) levels predict organ dysfunction in critically ill patients. Higher SDC-1 indicates increased risk for mortality and early signs of kidney, liver, and coagulation issues.
Area of Science:
- Biomarker discovery
- Critical care medicine
- Inflammatory response
Background:
- Syndecan-1 (SDC-1) is present in the endothelial glycocalyx.
- SDC-1 is released into circulation during systemic inflammation.
- Early detection of organ dysfunction in critical illness is crucial.
Purpose of the Study:
- To investigate the association between serum SDC-1 levels and organ dysfunction in critically ill patients.
- To evaluate SDC-1 as a potential early biomarker for organ dysfunction.
- To assess the relationship between SDC-1 and mortality risk.
Main Methods:
- Analysis of serum SDC-1 levels in 94 critically ill patients (831 samples).
- Utilized linear mixed effects models for repeated measures.
- Adjusted for age and sex in statistical analysis.
Main Results:
- Serum SDC-1 levels predicted changes in liver enzymes (AST, ALT), kidney function markers (creatinine, BUN), and coagulation parameters (antithrombin III, fibrin degradation products, D-dimer).
- SDC-1 levels modified the time-dependent effects on AST, ALT, creatinine, and BUN.
- Elevated SDC-1 was a significant predictor of mortality.
Conclusions:
- Serum SDC-1 is a potential biomarker for daily monitoring of kidney, liver, and coagulation function in critical care.
- SDC-1 may serve as an early indicator of organ dysfunction.
- Increasing serum SDC-1 levels are associated with increased mortality risk.
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