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The relationship between diabetes-related cognitive dysfunction and leukoaraiosis
Chun-Lan Yuan1, Ran Yi2, Qi Dong3
1Department of Neurology, The First Affiliated Hospital Of Harbin Medical University, No. 23 Youzheng Street, Harbin, 150001, People's Republic of China.
Acta Neurologica Belgica
|April 24, 2021
Summary
Diabetes mellitus (DM) significantly increases cognitive dysfunction risk. Leukoaraiosis (LA) and white matter hyperintensity (WMH) are key indicators, aiding early detection and management of brain changes in diabetic patients.
Area of Science:
- Neurology
- Endocrinology
- Radiology
Background:
- Cognitive dysfunction is linked to aging and neurodegenerative diseases.
- Diabetes mellitus (DM) is a significant risk factor for cognitive impairment.
- Increased leukoaraiosis (LA) and white matter hyperintensity (WMH) volume are observed in diabetes-related cognitive dysfunction.
Purpose of the Study:
- To review the epidemiology, pathogenesis, and imaging features of LA in diabetes-related cognitive dysfunction.
- To explore LA as a predictive marker for white matter lesions in DM patients.
- To discuss prevention and treatment strategies for LA pathophysiology in this population.
Main Methods:
- Review of existing literature on diabetes-related cognitive dysfunction and leukoaraiosis.
- Analysis of multimodal imaging findings in patients with DM and cognitive impairment.
- Synthesis of data on LA's role as a predictive signal for white matter lesions.
Main Results:
- Patients with diabetes-related cognitive dysfunction show a higher burden of LA and WMH.
- LA pathology serves as an emerging predictive signal for white matter lesions.
- Multimodal imaging aids in precise evaluation of central nervous system changes.
Conclusions:
- Leukoaraiosis is a significant finding in diabetes-related cognitive dysfunction.
- Early identification and diagnosis can be supported by recognizing LA pathology.
- Further research into prevention and treatment of LA in DM is warranted.
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