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Related Experiment Video

Updated: Nov 8, 2025

An Injectable and Drug-loaded Supramolecular Hydrogel for Local Catheter Injection into the Pig Heart
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Hydrogel-coated needles prevent puncture site bleeding.

Shunbo Wei1, Yanhua Xu2, Zhiwei Wang3

  • 1Department of Vascular and Endovascular Surgery, First Affiliated Hospital of Zhengzhou University, Henan 450052, China; Key Vascular Physiology and Applied Research Laboratory of Zhengzhou City, Henan, China.

Acta Biomaterialia
|April 24, 2021
PubMed
Summary

Hydrogel-coated needles effectively stop bleeding after vascular cannulation. This innovative approach may also promote healing by attracting vascular progenitor cells to the puncture site.

Keywords:
ArteryCannulationHemostasisHydrogelNeedlePunctureVein

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Area of Science:

  • Biomaterials Science
  • Vascular Surgery
  • Hemostasis

Background:

  • Incomplete hemostasis after vascular cannulation can lead to hematoma or pseudoaneurysm.
  • Developing effective methods for rapid hemostasis is crucial for patient outcomes.

Purpose of the Study:

  • To hypothesize and test the efficacy of hydrogel-coated needles for rapid hemostasis after vascular cannulation.
  • To investigate the potential of hydrogel coatings to promote puncture site healing.

Main Methods:

  • A hydrogel (sodium alginate, hyaluronic acid, calcium carbonate) was coated onto suture needles.
  • Needles were tested in mouse and rat models for vascular cannulation of various organs and vessels.
  • Histology and immunofluorescence were used to examine tissue response and cell recruitment.

Main Results:

  • Hydrogel-coated needles (22G and 30G) were successfully fabricated and confirmed via SEM.
  • Rapid hemostasis was achieved across multiple vascular puncture sites.
  • CD34 antibody-containing hydrogels attracted vascular progenitor cells and modulated macrophage M1/M2 balance.

Conclusions:

  • Hydrogel-coated needles provide an effective and rapid solution for puncture-site bleeding.
  • The CD34 antibody-functionalized hydrogel shows potential for enhancing vascular healing post-cannulation.